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在英格兰,宫癌的消除在眼前吗?

Clare Gilham¹, Julian Peto¹

¹Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK.

Preventive medicine

|January 5, 2025

概括

在英格兰,子宫癌的发病率很高,但HPV疫苗接种有望实现消除的目标. 需要持续监测,以评估新查方法对未接种疫苗的人群的影响.

科学领域:

在瘤学瘤学.
公共卫生公共卫生
流行病学流行病学

背景情况:

英格兰的年龄标准化宫癌率 (8.5/100,000) 超过了世卫组织的消除目标 (4.0/100,000).
尽管HPV疫苗接种和查覆盖率很高,但消除目标仍未实现.
历史死亡率趋势显示,HPV发病率在出生队列中发生了变化.

研究的目的:

评估英国目前的宫癌死亡率和发病率趋势是否表明消除癌症的进展.
分析查和HPV疫苗接种对子宫癌率的影响.

主要方法:

自1953年以来,按出生队列分析死亡率趋势.
自2000年以来,根据年龄组对癌症和癌症现场发生率的检查.
趋势与实施子宫部查和HPV疫苗接种计划的相关性.

主要成果:

在2000-2004年和2010-2014年期间,25-29岁的宫癌发病率翻了一番,死亡率增加了77%.
在1991年以来出生的人群中引入HPV疫苗接种后,发病率下降了90%在25岁以下和80%在25-29岁 (2015-2022年).
将查年龄从20岁提高到25岁,暂时增加了1984-1990年出生女性的发病率和死亡率.

结论:

对于NHS来说,HPV疫苗接种对于潜在地实现2040年宫癌消除目标 (4.0/100,000) 至关重要.
2019年转向初级HPV检测对未接种疫苗的老年人群的长期影响仍然不确定.
需要进一步的研究来了解疫苗接种和查策略的综合影响.

关键词:

宫癌是发生在宫癌的原因之一.英格兰英格兰英格兰英格兰.疫苗接种疫苗接种疫苗接种发生率趋势发生率趋势死亡率的趋势查检查查检查查检查

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