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Updated: Jun 4, 2025

Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation
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2M型·维勒布兰德病的结构解析动态

Alexander Tischer1, Laurie Moon-Tasson1, Matthew Auton1

  • 1Division of Hematology, Departments of Internal Medicine and Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA.

Journal of thrombosis and haemostasis : JTH
|January 5, 2025
PubMed
概括

2M型威尔布兰德病是由威尔布兰德因子 (VWF) 的A1域中的两个结构变化引起的. 这些变化要么使A1域过度稳定,要么错误折叠,从而损害了血小板粘附.

关键词:
-交换质谱仪质谱仪过度稳定性的超稳定.当地混乱局部混乱·威勒布兰德病是一种疾病.·维勒布兰德因素是什么

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