在微藻-细菌聚合物的热友性无氧消化过程中减少抗生素耐药性的机制
Julián O Ovis-Sánchez1, Miguel Vital-Jácome1, Germán Buitrón1
1Laboratorio de Investigación en Procesos Avanzados de Tratamiento de Aguas, Unidad Académica Juriquilla, Instituto de Ingeniería, Universidad Nacional Autónoma de México, Querétaro 76230, México.
Bioresource technology
|January 5, 2025
概括
热友性无氧消化有效地减少了微藻-细菌聚合物的抗生素耐药细菌和基因. 这种先进的废水处理策略可以减轻与抗生素耐药性相关的环境风险.
科学领域:
- 环境微生物学 环境微生物学
- 废水处理技术 废水处理技术
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 基于微藻和细菌的系统显示出对废水处理,去除营养素和抗生素耐药性的承诺.
- 然而,抗生素耐药性基因和细菌 (ARG和ARB) 可以在微藻-细菌聚合物 (MABA) 中繁殖.
研究的目的:
- 评估MABA的热友性 (55°C) 和中友性 (35°C) 连续无氧消化 (AD) 作为消除ARB和ARG的战略.
- 了解在不同温度调节下抵抗体减少背后的机制.
主要方法:
- 在热友和中友条件下MABA的持续无氧消化.
- 盘子计数技术用于量化ARB.
- 基于元基因组的分析,以评估ARG的丰富性和微生物社区结构.
主要成果:
- 热友性AD在减少ARB (1.11.7日志减少) 和ARG方面表现优越.
- 在热友条件下 (19.5 ± 0.8 ppm) 观察到ARG丰度的显著减少.
- 机制包括微生物组选择,移动组限制和增强的热应激抵抗.
结论:
- 热友性无氧消化是一种有效的方法来管理MABA中的抗生素耐药性.
- 这种方法对改善废水处理和减少与抗生素耐药性相关的环境风险具有重大影响.
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