相关实验视频

Updated: Jun 4, 2025

Viability Assays for Cells in Culture

Viability Assays for Cells in Culture

Published on: January 20, 2014

:通过神经调节和大脑病理进行导航

Ariba Khan¹, Poonam Sharma², Sarthak Dahiya¹

¹Department of Pharmacology, Amity Institute of Pharmacy, Amity University Uttar Pradesh, Noida, Uttar Pradesh, India.

Neuroscience and biobehavioral reviews

|January 5, 2025

概括

plexins和semaphorins是大脑发育和功能中的关键. 它们的失调与神经系统疾病 (如阿尔茨海默氏症和帕金森病) 有关.

科学领域:

神经科学是一个神经科学.
分子生物学分子生物学
发展生物学发展生物学

背景情况:

素是神经发育至关重要的跨膜受体,包括轴突引导和突触形成.
赛马福林作为plexin的连接体,调节轴突生长和中枢神经系统 (CNS) 中的神经元的定位.
素信号通路的失调与各种神经发育和神经退行性疾病有关.

研究的目的:

检查中枢神经系统中素和半素功能的分子和细胞机制.
为了阐明plexin失调在脑疾病的发病过程中的作用.
综合各种关于plexin参与神经疾病的研究结果.

主要方法:

对分子,细胞和动物模型研究的审查.
分析由分红素-复合素相互作用 (Rho和Ras GTPase网络) 触发的信号级联.
综合证据,将plexin失调与特定的大脑疾病联系起来.

主要成果:

plexins (A,B,C,D) 和semaphorins对于神经发生,神经元迁移和突触连接至关重要.
赛马福林-复合素结合激活了Rho和Ras GTPase信号通路.
异常的plexin信号与自闭症谱系障碍 (ASD),精神分裂症,阿尔茨海默病 (AD) 和帕金森病 (PD) 有关.

结论:

素是神经发育和连接性的关键调节者.
Plexin介导信号的干扰有助于许多大脑疾病的发展.
了解plexin通路为神经疾病提供了潜在的治疗点.

关键词:

阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.注意力缺陷多动障碍注意力缺陷多动障碍自闭症自闭症自闭症大脑中风脑中风脑中风是一种病.帕金森病是帕金森氏症的一种疾病.素 (Plexins) 是一种复合素.半氨酸 (semaphorins) 是一种半氨酸.

更多相关视频

Preparation of Acute Brain Slices Using an Optimized N-Methyl-D-glucamine Protective Recovery Method

Preparation of Acute Brain Slices Using an Optimized N-Methyl-D-glucamine Protective Recovery Method

Published on: February 26, 2018

Author Spotlight: A Personalized Approach Towards Investigating Alzheimer's Disease Using an In Vitro Blood-Brain Barrier Model

Author Spotlight: A Personalized Approach Towards Investigating Alzheimer's Disease Using an In Vitro Blood-Brain Barrier Model

Published on: October 20, 2023

相关概念视频

Neural Regulation

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.

Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...

The Blood-brain Barrier

The Blood-brain Barrier

Neuroplasticity

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.

Glial Cells

Glial Cells

Cytoskeletal Linker Proteins - Plakins

Cytoskeletal Linker Proteins - Plakins

Plakins are large proteins with binding domains for microtubules, microfilaments, intermediate filaments, and membrane-associated protein complexes at cell junctions. Plakin functions are evolutionarily conserved and are primarily involved in organizing the different components of the cytoskeleton by crosslinking them to each other and connecting them to the cell-matrix and cell adhesion complexes. They are also known to interact with signal transducers, serve as scaffolds for signaling...