机械改进的奇托桑/石墨烯氧化物纳米复合水凝,用于持续释放levofloxacin
Swati Sharma1, Manisha Bhende1, Priyanshi Mulwani1
1Dr. D.Y. Patil School of Science &Technology, Dr. D.Y. Patil Vidyapeeth, Pune 411033, India.
International journal of biological macromolecules
|January 5, 2025
概括
一种新的奇托/石墨烯氧化物纳米复合物水凝提供了增强的机械性能和可调节的胀,用于持续的levofloxacin输送. 这种材料对先进的药物输送应用有前途.
科学领域:
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
- 药物运输 药物运输 药物运输
背景情况:
- 基于酸盐的水凝因其生物相容性而被广泛用于药物输送.
- 加入氧化石墨烯 (GO) 可以增强水凝的机械强度和功能.
- 控制释放的抗生素,如levofloxacin对于有效的治疗和抗击耐药性至关重要.
研究的目的:
- 开发和表征一种新型的基多/石墨烯氧化物 (CS/GO) 纳米复合物水凝.
- 研究GO度对水凝机械性能,胀行为和药物释放动力学的影响.
- 评估CS/GO水凝作为持续输送levofloxacin的平台的潜力.
主要方法:
- 通过静电相互作用和化学交叉链接合成CS/GO纳米复合材料水凝.
- 机械性能的表征 (储存和损失模块).
- 在不同的GO度和pH值下评估胀行为.
- 在体外从水凝释放levofloxacin的药物释放研究.
主要成果:
- 合成的CS/GO水凝表现出显著的机械增强.
- 确认了GO在水凝矩阵内的均分布.
- 水凝表现出优异的膨胀特性,受GO含量和pH的影响.
- 利沃素释放动力学是可调节的,在较低的GO度下释放速度更快,在较高度下持续释放.
结论:
- CS/GO 纳米复合物水凝为药物输送提供了一个机械坚固和可调节的平台.
- 通过调整GO含量,可以调节勒沃素的受控释放.
- 这种新的水凝具有开发先进的,持续的药物输送系统的巨大潜力.
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