产前多环芳暴露和儿童生长和脂肪:一项纵向研究
Sarvenaz Shahin1, Akhgar Ghassabian2, Sophia M Blaauwendraad3
1Department of Pediatrics, New York University Grossman School of Medicine, New York, NY, United States.
Environmental research
|January 5, 2025
概括
产前暴露于多环芳 (PAHs) 与儿童增长的增加有关. 这项研究表明,PAHs可能在儿童生长轨迹的发育规划中发挥作用.
科学领域:
- 环境健康 环境健康
- 儿科健康 儿科健康
- 发育毒理学 发展毒理学
背景情况:
- 儿童暴露于多环芳 (PAHs) 与生长和脂肪的改变有关.
- 产前PAH暴露对儿童早期生长和肥胖的影响尚不清楚.
研究的目的:
- 调查产前暴露于PAHs与儿童早期生长和肥胖之间的联系.
- 探索PAHs对儿童生长的发育规划影响.
主要方法:
- 这项研究包括来自纽约大学儿童健康与环境研究 (2016-2019) 的880对母婴对.
- 在怀孕期间测量了孕妇尿液PAH代谢物.
- 儿童生长参数 (体重,身长/身高,皮厚度) 每年评估,直到4岁.
- 用对共变量调整的线性混合效应模型来分析关联.
主要成果:
- 较高的产前PAH暴露与儿童体重和长度/身高z-score的增加相关.
- 在较晚的年龄 (3岁和4岁) 中,PAH暴露和生长指标之间的关联更为强烈.
- 特定的PAH代谢物,如2-NAP,2-PHEN,1-PYR和4-PHEN,与更高的体重z分数显著相关.
结论:
- 产前暴露于PAHs可能会影响儿童成长的发育规划.
- 研究结果强调了在关键发育窗口期间环境暴露的潜在长期影响.
相关概念视频
Attention-Deficit/Hyperactivity Disorder
36
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
36
Nature and Nurture
20.4K
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
20.4K
Teratogenicity
2.3K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.3K
Lung Capacity
49.3K
The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
49.3K
Types of Toxins
1.6K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.6K
Cancer Prevention
6.0K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.0K


