在接受阿特佐利祖马布加贝瓦西祖马布联合治疗的患者中呈现伪进展的肝细胞癌
Takahiro Osuga1, Tomohiro Kubo1, Koji Miyanishi1
1Department of Medical Oncology, Sapporo Medical University School of Medicine, Japan.
Internal medicine (Tokyo, Japan)
|January 5, 2025
概括
伪进展,最初表现为疾病恶化,可能表明肝细胞癌患者对阿特佐利祖马布和贝瓦齐祖马布治疗的良好反应. 这种现象表明长期治疗成功的积极预后因素.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 肝胆道癌症 肝胆道癌症
背景情况:
- 肝细胞癌 (HCC) 是一种主要的肝癌,在全球有显著的死亡率.
- 先进的HCC通常需要全身治疗,使用免疫检查点抑制剂和抗血管原体药物显示有前途.
- 区分真正的疾病进展和与治疗相关的现象,如伪进展,对于患者管理至关重要.
研究的目的:
- 报告一个肝细胞癌病例与肺转移,用阿特佐利祖马布和贝瓦西祖马布治疗.
- 调查该患者的伪进展现象及其随后的结果.
- 在HCC中探索潜在的预测生物标志物,用于对阿特佐利祖马布和贝瓦齐祖马布治疗的反应.
主要方法:
- 一个单一机构的病例报告,65岁的男性患者患有晚期HCC.
- 用阿特佐利祖马布和贝瓦西祖马布组合治疗.
- 序列CT成像用于响应评估和瘤组织组织学检查.
主要成果:
- 患者最初出现了新的肝病变和发烧,被解释为伪进展.
- 继续治疗导致了新的病变的解决和原发性瘤和转移的收缩.
- 实现了部分反应,并持续了两年.
- 组织学显示CD8阳性淋巴细胞和PD-L1阳性巨细胞,可能预测反应.
结论:
- 在治疗HCC的阿特佐利祖马布和贝瓦齐祖马布治疗期间,可能会发生伪进展.
- 伪进展可能是治疗反应良好的早期迹象,也是HCC的积极预后因素.
- 免疫细胞透模式可以预测HCC免疫疗法组合的反应.
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