在一只狗中具有粘膜腺分化的acanthomatous ameloblastoma
Takayuki Mineshige1,2, Satoshi Takagi2,3, Takanori Shiga4
1Laboratory of Clinical Diagnostics, School of Veterinary Medicine, Azabu University, Kanagawa, Japan.
The Journal of veterinary medical science
|January 5, 2025
概括
一个罕见的犬类白性乳腺母细胞瘤 (CAA) 病例显示出异常的粘膜腺分化. 综合性分析对于准确诊断这种不常见的口腔瘤至关重要.
科学领域:
- 兽医病理学 兽医病理学
- 口腔瘤学 口腔瘤学
- 狗的新生病 狗的新生病
背景情况:
- 狗状腺母细胞瘤 (CAA) 是一种常见的良性口腔瘤.
- 不典型的CAA呈现需要彻底调查.
- 在CAA中以前没有报告过粘性腺体分化.
研究的目的:
- 报告一例未经证实的犬类形腺母细胞瘤与粘膜腺分化的病例.
- 强调详细的组织病理学和免疫组织化学分析在诊断口腔瘤中的重要性.
- 为了解兽医学中罕见的瘤变异做出贡献.
主要方法:
- 活检和计算机断层扫描 (CT) 用于初步诊断和分期.
- 下质量的外科切除.
- 详细的组织病理学检查包括免疫组织化学 (cytokeratin AE1/AE3,cytokeratin CAM5.2) 和Alcian蓝色染色.
主要成果:
- 一只12岁的奇华娃出现了右下质量,最初被诊断为CAA.
- CT显示了显著的骨溶解.
- 组织学证实了CAA,其中有一小部分瘤细胞群体表现出粘膜腺分化,这是一个新发现.
- 免疫组织化学和特殊染料证实了腺细胞和粘素的产生.
- 低线粒体和Ki-67扩散指数表明低度恶性瘤.
结论:
- 这一案例代表了首次记录在案的状腺分化的案例,在狗的acanthomatous ameloblastoma.
- 准确的诊断需要综合性组织病理学和免疫组织化学评估,以区别于其他口腔瘤.
- 这一发现扩大了犬口腔瘤中已知的组织学变异的范围.
相关概念视频
01:16Cell Motility through Blebbing
Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
Blebbing Through the Matrix
In multicellular...
01:29Exocrine Glands: Unicellular and Multicellular Glands
Exocrine glands are classified as unicellular and multicellular. The unicellular glands are scattered single cells, such as goblet cells, found in the mucous membranes of the small and large intestines. On the other hand, multicellular exocrine glands develop as secretory sheets, like the internal lining of the abdomen or chest. Such secretory sheets release their secretions directly into the lumen of these organs. In addition, some multicellular glands have deep-seated secretory units to...
01:21Tooth Anatomy
The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.
01:19Appendicitis
Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...