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一个简单的合成Pinocembrin

Kento Iwai^1,2,3, Nagatoshi Nishiwaki^1,2

¹School of Engineering Science, Kochi University of Technology.

Journal of oleo science

|January 5, 2025

概括

从肉酸和1,3,5-三基烯中合成皮诺布林的新一两步合成方法,为传统方法提供了成本效益高且简化的替代方案,避免了基组保护.

科学领域:

有机合成有机合成
自然产品化学自然产品化学

背景情况:

皮诺坎布林是一种天然存在的石,具有各种生物活动.
传统的皮诺布林合成涉及多个步骤和昂贵的试剂.
在传统的合成途径中,通常需要保护基基.

研究的目的:

开发一种简单,高效和具有成本效益的合成方法,用于pinocembrin.
为了避免在pinocembrin的合成中需要保护组.
提供使用易于获得的原材料的替代合成途径.

主要方法:

一,两步反应. 一个,两步反应.
在 cinnamic 酸中生成 cinnamoyl 化物.
化与1,3,5-三基在化 (AlCl₃) 的存在下发生的反应.
使用廉价的化学试剂和溶剂,如N,N-二甲基形式胺 (DMF),1,2-二乙烯 (DCE) 和酸 (PhNO).

主要成果:

在一,两步程序中成功合成皮诺布林.
该方法使用廉价的原料:酸和1,3,5-三基.
消除了保护基基的需要.
与传统方法相比,简化了实验程序.

结论:

开发的合成方法是一种实用和经济的方法,用于生产皮诺坎布林.
这种方法在简单性和成本方面比传统路线提供了显著的优势.
避免保护组可以提高合成过程的效率.

关键词:

这是一种flavanone.在分子内结合的加法.没有保护的免费保护.

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