在H. pylori负性胃肉瘤的临床特征和时间趋势
Ali Hajj Ali1, Mohamad Ali Ibrahim1, Ayman Alrazim1
1Division of Gastroenterology and Hepatology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
概括
杆菌阴性胃MALToma病例正在增加,并且对根除治疗的反应有所减少. 尽管临床特征相似,但H. pylori阴性MALToma患者需要不同的管理策略.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 粘膜相关淋巴组织 (MALT) 淋巴瘤或MALToma是一种胃非霍奇金淋巴瘤.
- 胃MALToma主要与Helicobacter pylori (H. pylori) 感染有关.
- 胃MALTomas的一个子集发生在H.pylori阴性 (HPN) 个体中,并且可能遵循不同的临床过程.
研究的目的:
- 调查H. pylori阴性 (HPN) 胃MALToma的临床特征和治疗结果.
- 为了将HPN MALToma患者与H. pylori阳性 (HPP) MALToma患者进行比较.
- 分析随着时间的推移HPN MALToma诊断和治疗反应的趋势.
主要方法:
- 在2000年至2021年间诊断的胃MALToma患者的回顾性分析.
- H. pylori 阴性状态通过至少两次阴性诊断测试得到证实.
- 患者被分为H.pylori阳性 (HPP) 和H.pylori阴性 (HPN) 组进行比较.
主要成果:
- 在52名胃MALToma患者中,48.1%为HPN.
- 近年来观察到HPN MALToma的患病率较高 (2011-2021年与2000-2010年相比).
- HPN患者的根除疗法 (ET) 成功率较低 (25%对1期HPP的78.6%),并且接受了更多的化疗/放射治疗 (86.4%对57.1%).
- 在HPP和HPN组之间,治疗结果是可比的.
- ET响应者更有可能是HPP,并且更早地被诊断出来.
结论:
- HPN胃MALToma患者与HPP同行有临床相似之处.
- 在HPN MALToma诊断方面有越来越多的趋势.
- 近年来,HPN MALToma患者对根除疗法的反应正在下降.
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