在线多内部标准校准的应用,以通过ICP-MS确定
Long-Hua Zhou1, Xing-Chen Lin1, Li-Li Suo1
1Physical and Chemical Department, The Collaboration Unit for Field Epidemiology of State Key Laboratory for Infectious Disease Prevention and Control, Nanchang Centre for Disease Control and Prevention, Nanchang, China.
Journal of mass spectrometry : JMS
|January 5, 2025
概括
在线多内部标准校准 (M.ISC) 提供了一种有效的方法,用于确定使用ICP-MS.MS的度. 这种技术简化了校准,减少了浪费,与传统方法相比提高了准确性.
科学领域:
- 分析化学 分析化学
- 环境科学 环境科学
- 质谱测量质量谱测量
背景情况:
- 准确的测定对于各种应用至关重要,包括环境监测和生物样本分析.
- 使用ICP-MS进行分析的传统校准方法可能耗时且产生大量浪费.
- 传统的内部标准 (IS) 方法需要物种识别,这增加了分析工作流程的复杂性.
研究的目的:
- 通过ICP-MS.全面评估在线多内部标准校准 (M.ISC) 用于通过ICP-MS.确定的应用.
- 与传统方法相比,评估M.ISC的效率,准确性和减少废物的好处.
- 用标准参考样本和LOD/LOQ计算的错误传播来验证M.ISC的性能.
主要方法:
- 在线多内部标准校准 (M.ISC) 用于量化.
- 诱导合等离子体质谱 (ICP-MS) 被用作主要分析技术.
- 使用传统化学分析方法 (TCAM),外部标准校准 (EC) 和单一IS方法进行了比较分析.
主要成果:
- M.ISC简化了校准过程,只需要一个标准解决方案.
- 该方法有效地减少信号偏差,同时利用多个IS物种,避免了物种识别的需要.
- 使用六个标准参考样本的验证证明了M.ISC的有效性,通过错误传播确定LOD和LOQ.
结论:
- M.ISC提供了一种简单有效的矩阵校正策略,用于ICP-MS检测.
- 这种方法在简单性,吞吐量和废物最小化方面比传统校准技术有了显著的改进.
- M.ISC代表了常规分析的有价值替代品,提高了实验室效率和分析可靠性.
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