相关实验视频
Updated: May 7, 2025

07:20
Author Spotlight: Imaging ATG9A, a Multi-Spanning Membrane Protein
Published on: June 16, 2023
1.9K
在植物中,ATG8脱脂并不是对植物自的普遍关键
Yong Zou1, Jonas A Ohlsson1, Sanjana Holla1
1Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala, Sweden.
Nature communications
|January 5, 2025
概括
自自是一种自的过程.
科学领域:
- 细胞生物学 细胞生物学
- 分子生物学分子生物学
- 植物科学 植物科学
背景情况:
- 自是一种细胞循环过程,由自相关蛋白质 (ATG) 的翻译后修改调节.
- ATG8的ATG4依赖性脱脂对于自细胞形成至关重要,在酵母和哺乳动物中发挥着不同的作用.
研究的目的:
- 研究ATG8脱脂在绿藻Chlamydomonas reinhardtii和血管植物Arabidopsis thaliana中自细胞形成中的作用.
- 了解植物自机制的进化分歧.
主要方法:
- 在Chlamydomonas reinhardtii和Arabidopsis thaliana中对与自相关的 (ATG) 基因进行比较分析.
- 在压力条件下调查ATG4介导的ATG8脱脂对于自细胞形成和自细胞流量的必要性.
主要成果:
- 阿拉比多普西斯塔利亚纳的复杂的自机械使得ATG8脱脂对于自细胞成熟和承受压力是不可或缺的.
- 克拉米多莫纳斯强硬菌的自完全依赖于ATG4介导的ATG8脱脂.
- 不同的阿拉比多普西斯ATG8正体对自细胞形成有不同的影响,特别是在耗下.
结论:
- 这项研究揭示了真核细胞系中自细胞成熟机制的进化多样化.
- 自途径是根据不同生物体的特定需求量身定制的,例如植物ATG8脱脂的独特作用.
相关概念视频
Autophagy
4.0K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
4.0K
Delivery Pathways to the Lysosome
6.1K
Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
6.1K
Protein Transport to the Inner Chloroplast Membrane
2.0K
Proteins targeted to the inner chloroplast membrane, or plastid proteins, are transported by two general pathways: the stop-transfer and the re-insertion or post-import pathways. Most plastid proteins carry N-terminal transit sequences and internal import sequences targeting it to the specific chloroplast subcompartment. Proteins targeted by the stop-transfer pathway have internal hydrophobic sequences that inhibit their translocation into the stroma. As a result, these precursors are arrested...
2.0K
Protein Transport to the Thylakoids
2.2K
Thylakoids are membrane-bound sac-like structures within the chloroplast that serve as sites for photosynthesis. Thylakoid lumen contains many electron transport proteins and is enclosed by a thylakoid membrane rich in the light-harvesting complex. Proteins targeted to the thylakoids are transported as precursors and are sorted by the general TOC/TIC import pathway. Once the precursor reaches the stroma, stromal processing peptidases remove their transit signal and expose thylakoid signal...
2.2K
Autophagic Cell Death
2.7K
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
2.7K
Protein Transport to the Outer Chloroplast Membrane
1.9K
Chloroplast outer membrane proteins encoded by the nucleus are synthesized in the cytosol. Soon after synthesis, they bind cytosolic factors such as 14-3-3 protein and the Hsp70 chaperones that keep these precursors in an unfolded state until their translocation.
Two models describe the mechanism of precursor recognition and entry across the outer membrane through the TOC complex. Model 1 suggests the newly synthesized precursor binds to the TOC receptor 159 and forms a complex.
Two models describe the mechanism of precursor recognition and entry across the outer membrane through the TOC complex. Model 1 suggests the newly synthesized precursor binds to the TOC receptor 159 and forms a complex.
1.9K

