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内部表达和与其他内皮决定因素的相关性,用于开发糖尿病外围神经病变的早期识别得分

Prajna Parimita Jena¹, Rachita Nanda², Amritava Ghosh³

¹Department of Biochemistry, All India Institute of Medical Sciences Raipur, GE Road, Tatibandh. Raipur, Raipur, Chhattisgarh, 492099, India.

Scientific reports

|January 5, 2025

概括

内皮功能障碍的生物标志物,包括内,在糖尿病外围神经病变中发生变化. 测量这些标志物可能有助于早期识别高风险糖尿病患者.

科学领域:

内分泌学在内分泌学.
血管生物学血管生物学
代谢疾病代谢疾病

背景情况:

糖尿病外围神经病变 (DPN) 是一种常见的糖尿病并发症,具有重大经济影响.
尽管DPN具有多因素性质,但其致病的确切机制仍然不清楚.
由内分泌等生物标志物表明的内皮功能障碍是DPN发展的新兴因素.

研究的目的:

在患有糖尿病外围神经病变的患者中研究内皮细胞生物标志物.
评估DPN中内分泌,hs-CRP,维生素D和脂质资料之间的关系.
探索这些生物标志物的潜力,以早期对DPN风险分层.

主要方法:

一项涉及49名患有糖尿病和外围神经病变的患者和48名患有糖尿病但没有神经病变的患者的横截面研究.
测量和分析内皮细胞生物标志物:内分泌,hs-CRP,维生素D和脂质资料.
计算失脂症,炎症,维生素D和内分泌的标准化得分.

主要成果:

在DPN患者中观察到内分泌,hs-CRP,维生素D和脂质配置文件的显著变化.
在内分泌水平和脂质配置文件之间发现了强烈的相关性.
在hs-CRP和维生素D水平之间发现了显著的相关性.

结论:

在糖尿病外围神经病变中,内皮细胞生物标志物显著改变.
炎症和综合生物标志物评分可能有助于早期对DPN风险分层.
对内皮功能障碍标记物的进一步研究可以改善DPN管理.

关键词:

血神经屏障血神经屏障细胞因子 (cytokines) 是一种细胞因子.潜水分数得分潜水分得分脱脂血症是什么意思脱脂血症是什么意思内皮内皮细胞内皮细胞内皮细胞内皮炎症炎症是一种炎症.

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