从大脑大小解开性对大脑组织和认知功能的影响
Aliza Brzezinski-Rittner1,2,3, Roqaie Moqadam4,5,6, Yasser Iturria-Medina7,8,9,10
1Cerebral Imaging Center, Douglas Mental Health University Institute, 6875 Boulevard LaSalle, Montréal, QC, H4H 1R3, Canada. aliza.brzezinskirittner@mail.mcgill.ca.
GeroScience
|January 5, 2025
概括
总内体积 (TIV) 混了性别差异的神经成像研究. 这项研究解开了TIV效应,揭示了大多数观察到的大脑大小变化与TIV相关,而不是性别特异.
科学领域:
- 神经科学是一个神经科学.
- 人类生物学 人类生物学
- 认知科学 认知科学
背景情况:
- 大脑成像中的神经解剖学性差异通常被总内体积 (TIV) 混.
- 了解真正的性别差异化大脑衰老需要控制TIV.
- 以前的研究可能高估了由于TIV效应的性别差异.
研究的目的:
- 将TIV与生物性别对大脑结构和衰老的影响分开.
- 研究性别差异化大脑衰老轨迹,功能网络和细胞架构.
- 检查TIV对认知性差异的影响.
主要方法:
- 在英国生物库数据上使用因果建模匹配方法.
- 创建了操纵TIV差异以隔离性别效应的子样本.
- 在这些子样本中比较区域和顶点级性别估计.
主要成果:
- 观察到的与性别有关的神经解剖学差异在与TIV匹配的子样本中显著减少.
- 以前掩盖的双向性差异在大脑解剖学中,在对TIV进行控制后出现.
- 在推理和记忆方面的认知性差异显示,在匹配后方向发生了变化.
结论:
- 总内体积是性别差异的神经成像研究的主要混因素.
- 大脑解剖学中大多数明显的性别差异都归因于TIV.
- 控制TIV可以更清楚地了解性别差异化大脑衰老和认知.
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