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Updated: May 7, 2025

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组胺H3受体抗剂/逆agonists:一个专利审查 (2017年10月 - 2023年12月) 记录进展
Dorota Łażewska1, Katarzyna Kieć-Kononowicz1
1Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, Kraków, Poland.
Expert opinion on therapeutic patents
|January 6, 2025
概括
组胺H3受体 (H3R) 抗剂/逆agonists是关键的药物开发目标,特别是对于中枢神经系统疾病. 最近的专利显示,专注于多目标化合物和新的治疗用途,如自闭症.
科学领域:
- 药用化学 医学化学
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 组胺H3受体 (H3R) 抗剂/逆agonists是药物发现中的关键配体.
- H3R主要位于中枢神经系统 (CNS),使其成为神经和精神疾病的关键目标.
研究的目的:
- 审查2017年10月至2023年12月期间公布的与H3R抗剂/逆agonists相关的专利申请和专利.
- 概述目前的H3R研究格局,包括方法,化合物和治疗指示.
主要方法:
- 在 Espacenet 和 PatentScope 数据库中搜索专利文件.
- 分析了51项专利申请/专利,重点是H3R抗剂/逆激动剂.
- 与PubMed,Scopus和ClinicalTrials数据库中的文献进行了交叉引用.
主要成果:
- 许多涉及H3R抗剂/逆agonists的药物成分已被专利.
- 研究趋势显示,转向多标化合物和探索新型治疗领域.
- 报道了H3R与配体的第一个晶体结构,进步了结构理解.
结论:
- 对H3R的兴趣仍然很高,目前正在进行的研究重点是开发新型联体和治疗应用.
- 新的临床试验正在研究H3R对抗剂治疗自闭症,疲劳和普拉德-威利综合征等疾病.
- 该领域正在向基于H3R的治疗方法的更复杂,多目标的方法发展.
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