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Rui Zhang1, Jiangfeng Mao2, Min Nie2
1Endocrinology Center, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Clinical endocrinology
|January 6, 2025
概括
荷尔蒙疗法可以改善先天性性性性症 (CHH) 的男性的身体组成和新陈代谢,但不能完全恢复健康水平. 水平与改善的身体脂肪,肌肉质量,骨密度和瘦素水平相关.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 身体组成分析 身体成分分析
背景情况:
- 先天性性性性性 (CHH) 是一种影响成年男性的病症,其特征是的产生受损.
- 激素替代疗法 (HRT) 对CHH患者的身体组成和代谢健康的长期影响需要进一步阐明.
研究的目的:
- 评估激素疗法对CHH成年男性体质组成,阿迪波金和代谢参数的长期影响.
- 为了比较治疗CHH患者,未治疗CHH患者和健康对照患者之间的结果.
主要方法:
- 招募66名CHH患者 (33名接受治疗,33名未接受治疗) 和21名健康对照.
- 使用双能X射线吸收计 (DXA) 评估身体成分.
- 测量血清阿迪波金和代谢参数,包括,莱普丁,阿迪波内克丁,HOMA-IR和QUICKI.
主要成果:
- 与未接受治疗的患者相比,接受治疗的CHH患者的丸激素水平有所改善,身体脂肪 (百分比和内脏脂肪组织) 减少,肌肉软组织和骨矿物质含量增加.
- 在CHH患者中,激素治疗导致瘦素降低,阿迪波涅丁改善,以及更好的葡萄糖脂代谢 (HOMA-IR, QUICKI).
- 虽然激素疗法改善了参数,但接受治疗的CHH患者与健康对照人群相比,身体组成和代谢标志物仍然存在一些差异.
结论:
- 未经治疗的CHH与不良的身体组成,阿迪波金样本和代谢障碍有关.
- 激素疗法在CHH中对身体组成和葡萄脂代谢具有显著的益处,尽管与健康个体相比,正常化并不总是实现的.
- 在CHH中异常的代谢参数与脂肪量增加和瘦素水平的改变有关,血清丸激素水平与瘦素有显著的负相关性.
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