克罗恩病的简单内镜评分 (SES-CD) ≥7预测疾病的进展
Jellyana Peraza1, Marco Emilio Kaper2, Andre Bargas3
1The Dr. Henry D. Janowitz Division Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
克罗恩病的简单内镜评分 (SES-CD) 值为7或更高,预测轻度克罗恩病的疾病进展. 6分或更低的分数可以识别患有进展风险较低的患者.
科学领域:
- 胃肠病学 胃肠病学
- 炎症性肠道疾病研究研究
- 临床内镜检查 临床内镜检查
背景情况:
- 克罗恩氏病 (CD) 影响高达30%的轻度疾病病程的患者,但缺乏对轻度CD的共识定义.
- 识别轻度CD患者对于预测长期结果和定制治疗策略至关重要.
研究的目的:
- 为了确定克罗恩病简单内镜评分 (SES-CD) 的值,与长期疾病进展的可能性降低最为密切相关.
- 根据内镜检查结果,为轻度克罗恩病提供潜在的定义.
主要方法:
- 一项多中心的回顾性队列研究,涉及177名美国和欧洲第三级护理中心的手术前CD患者.
- 在患者没有接受免疫抑制疗法时进行了内镜评估.
- 疾病进展被定义为系统性类固醇,生物制剂或免疫调节剂的开始;新的严格/透并发症;或CD相关的住院治疗/手术. 考克斯的比例危险建模分析了2岁和5岁的进展预测因素.
主要成果:
- 在2年后的23%患者和5年后的35%患者观察到疾病进展.
- 用SES-CD测量的内镜严重程度,独立预测疾病进展.
- 7或更高的SES-CD与与0.0的SES-CD相比,在2年 (HR 2.50) 和5年 (HR 2.89) 的进展风险显著增加.
结论:
- 7或以上的SES-CD得分是轻度克罗恩病患者疾病进展的重要预测指标.
- 6或更低的SES-CD得分可能有助于识别患有进展风险较低的个体,可能有助于定义轻度CD.
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