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Updated: Jun 3, 2025

Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing
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增加的p16Ink4a表达增强了从人类诱导的多能干细胞分化的神经元中的陶酸化

Kristopher Holloway1, Kashfia Neherin1, Yingduo Song2

  • 1Department of Pediatrics, 3 NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.

Aging cell
|January 6, 2025
PubMed
概括

循环素依赖的激酶抑制剂p16Ink4a (p16) 通过增加神经元中的陶酸化来加剧阿尔茨海默病 (AD) 病理. 这表明p16和tau之间的正反循环,有助于AD的进展.

关键词:
阿尔茨海默病的疾病阿尔茨海默病的疾病.老化的老化 衰老的老化细胞衰老 细胞衰老疾病建模 疾病建模p16Ink4a的使用情况知道了,就知道了.

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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