连续射精对精子参数的影响在男性的Oligo-astheno-teratozoospermia (OAT) 中
Akram Hosseini1,2, Zahra Borzouie1,2, Parvin Khalili3,4
1Associated professor of the Department of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Zygote (Cambridge, England)
|January 6, 2025
概括
初次射精后短暂的1-2小时禁欲期可能会改善精子质量. 这种策略增强了运动性,形态学和DNA完整性,为男性不孕症患者提供了一个简单的解决方案,特别是那些患有oligo-astheno-teratozoospermia (OAT) 的患者.
科学领域:
- 生殖医学 生殖医学
- 安德罗学与人类学
- 精子分析 精子分析
背景情况:
- 目前世界卫生组织的指导方针建议在精液分析前禁欲2-7天.
- 新出现的证据表明,更短的禁欲期可能会产生优越的精子质量参数.
- 需要进一步的研究来验证更短的戒断期是否适用于临床应用.
研究的目的:
- 为了比较精子质量和DNA完整性,标准 (2-7天) 和短 (1-2小时) 禁欲期在男性中与oligo-astheno-teratozoospermia (OAT).
- 为了评估功能性精子参数,在短暂的禁欲间隔后第二次射精后.
主要方法:
- 50名被诊断患有OAT的男性提供了两个精液样本.
- 第一个样本遵循标准的2-7天禁欲期 (长AP).
- 第二个样本是在第一个样本 (短AP) 后1到2小时内采集的,并对所有参数进行了比较.
主要成果:
- 第二次射精 (简称AP) 显示出明显更高的渐进性运动,非渐进性运动,形态和活力 (P<0.05).
- 短AP还导致不动精子数量降低和DNA碎片化 (P<0.05).
- 相反,精子度,精子总数和精液体积在第一次射精 (长AP) 中较高.
结论:
- 额外的短暂禁欲期 (1-2小时) 可能是一个简单而有效的策略,以改善精子质量,特别是对于OAT患者.
- 这些发现表明,目前关于精液分析中禁欲期的指导方针可能需要对严重的男性因子不孕症进行修订.
- 重视禁欲期建议可以提高诊断准确性和治疗疗效在男性不孕症管理.
相关概念视频
01:41Spermatogenesis
102.1K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
102.1K
01:23Infertility in Males
241
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
241
01:15Sperm Transport
635
The journey of sperm from its origin to the point of ejaculation begins within the seminiferous tubules of the testis. Here, Sertoli cells produce fluid that propels non-motile sperm through a series of conduits, starting with the straight tubules leading to the rete testis. This interconnected network of tubules acts as the initial pathway for sperm, guiding them into the efferent ductules and then into the epididymis for maturation.
The maturation phase occurs in the epididymis, where sperm...
The maturation phase occurs in the epididymis, where sperm...
635
02:07Oogenesis
63.4K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.4K
01:22Sperm Structure and Semen Composition
1.2K
During ejaculation, males release around 2-5 milliliters of semen, which is a complex mixture of mature sperm and various fluids produced by accessory glands. The mature sperm cells measure approximately 60 micrometers in length and consist of a head, neck, midpiece, and tail. The head is flattened and tapered, measuring about 4 to 5 micrometers in length. It contains a nucleus with condensed chromosomes and an acrosome, a cap-like structure filled with enzymes essential for penetrating the...
1.2K