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研究质量,年龄和地理因素对Pcos患病率的影响 - 一个系统性审查和元分析

Mina Amiri¹, Sana Hatoum¹, Richard P Buyalos^1,2

¹Foundation for Research and Education Excellence, Vestavia, AL, USA.

The Journal of clinical endocrinology and metabolism

|January 6, 2025

概括

全球多囊性卵巢综合征 (PCOS) 患病率因诊断标准和年龄而异. 高质量的研究显示,没有明显的区域差异,强调需要强大的评估工具,如PEP工具.

科学领域:

生殖内分泌学生殖内分泌学
流行病学流行病学
妇女健康妇女健康

背景情况:

多囊卵巢综合征 (PCOS) 是一种广泛存在的内分泌疾病,对健康有重大影响.
现有的PCOS全球流行病学数据有限,这阻碍了全面的理解.

研究的目的:

进行多囊性卵巢综合征 (PCOS) 患病率的全球估计.
分析PCOS在不同诊断标准和人口群体中的流行情况.

主要方法:

在PubMed和Embase数据库中系统地搜索PCOS研究在未经选择的人群中的文献,直到2024年2月.
包括88项涉及561,287名女性的研究,使用PCOS流行病学和表型 (PEP) 工具进行质量评估.

主要成果:

鹿特丹标准确定了最高的PCOS流行率,其次是AE-PCOS和NIH标准. 高质量的研究报告了10.89% (罗德丹),10.61% (AE-PCOS) 和6.63% (NIH) 的流行率.
在使用NIH或鹿特丹标准的高质量研究中,没有发现PCOS患病率的显著区域差异. 非洲地区的数据明显缺失.
在使用NIH标准的成年人与青少年中观察到更高的患病率,尽管这种差异在高质量的研究中减少了.

结论:

全球PCOS患病率估计受诊断标准和研究质量的影响.
这些发现强调了使用标准化质量评估工具 (如PEP工具) 进行准确的PCOS流行病学元分析的重要性.
需要进一步的研究来解决数据缺口,特别是在代表性不足的地区和特定年龄组.

关键词:

多囊性卵巢综合征多囊性卵巢综合征青少年青少年青少年青少年流行病学流行病学地理变化地域变化患病率的流行情况.质量评估质量评估的质量评估.

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