探索口腔和肠道微生物群对性粘膜炎的影响:试点队列研究
Valentin Bartha1, Sébastien Boutin2,3, Dorothée L Schüßler1
1Department for Conservative Dentistry, School of Dental Medicine, University Heidelberg, Heidelberg, Germany.
Oral diseases
|January 6, 2025
概括
在全源干细胞移植 (aSCT) 期间的性粘膜炎与特定的口腔和肠道微生物组变化有关. 在发病的患者中观察到唾液中Mycoplasma salivarius的增加和随期的减少.
科学领域:
- 微生物组研究的研究.
- 胃肠病学 胃肠病学
- 血液学 血液学 血液学
背景情况:
- 性粘膜炎是全原干细胞移植 (aSCT) 的常见并发症.
- 口腔和肠道微生物组在SCT相关并发症中的作用尚未完全理解.
研究的目的:
- 在aSCT期间比较患有性粘膜炎和没有性粘膜炎的患者的口腔和肠道微生物组概况.
- 为了识别与性粘膜炎发展相关的微生物特征.
主要方法:
- 16S-rRNA基因测序用于分析口腔粘膜,唾液和便样本.
- 样本采集在 (T0) 之前和 (T1) aSCT之后.
- 研究了微生物组结构差异和与临床特征的关联.
主要成果:
- 40%的患者出现了.
- 微生物群多样性在aSCT后减少,不论是.
- 患有的患者表现出唾液 Mycoplasma salivarius 的增加和开始的减少.
- 肠道微生物组的改变,包括Enterococcus spp. 在两组中都注意到过剩,过剩.
结论:
- 唾液和肠道中明显的微生物变化与aSCT后的性粘膜炎有关.
- 唾液中的Mycoplasma salivarius和减少的共生体是粘膜炎的潜在生物标志物.
- 了解这些微生物组变化可能会为预防或管理粘膜炎的策略提供信息.
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