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障碍中的崩的回顾:牙科疾病中的紧关节功能障碍

Thao Thi Do¹, Vy Thuy Nguyen¹, Ngoc Tran Nhu Nguyen¹

¹Oral Diagnosis and Periodontology Department, Faculty of Odonto-Stomatology, Can Tho University of Medicine and Pharmacy, Can Tho City, 900000, Vietnam.

Clinical, cosmetic and investigational dentistry

|January 6, 2025

概括

紧接点 (TJs) 调节上皮质的透性,但它们在极性中的作用仍在争论中. 关功能障碍,特别是由于细菌感染,在牙科疾病中显著损害口腔上皮质屏障.

科学领域:

细胞生物学细胞生物学
口腔生物学口腔生物学
病理学病理学病理学

背景情况:

紧接点 (TJs) 是关键的细胞-细胞接点,调节表皮和内皮的透性和细胞极性.
关键的TJ成分包括膜蛋白,如奥克卢丁,克劳丁和结合粘附分子.
关于TJs在维持上皮质极性中的确切作用,存在相互矛盾的证据.

研究的目的:

探索紧接点 (TJ) 功能障碍在口腔上皮屏障分解中的作用.
调查TJ功能障碍与各种牙科疾病的进展之间的潜在联系.
呈现TJ参与口腔病理学的新视角.

主要方法:

文献综述和现有关于紧张结节和牙科疾病的研究综合.
对研究TJ成分及其在口腔组织中的表达的研究进行分析.
检查将细菌感染与口腔条件下的上皮质屏障破坏联系在一起的证据.

主要成果:

关功能障碍与牙上皮质屏障受损和口腔疾病进展有关.
细菌感染可以直接损害细胞间连接或改变TJ蛋白表达.
细菌诱导的炎症性细胞因子可能会降低TJ蛋白的调节,进一步损害上皮屏障.

结论:

紧接位功能障碍是口腔上皮质屏障分解的一个重要因素.
这种功能障碍与牙科疾病的发病和进展有关,包括牙炎,牙周炎,Sjögren综合征和口腔平细胞癌.
了解TJ角色为口腔疾病提供了新的治疗点.

关键词:

这是Sjögren综合征.表面上皮质屏障的一个障碍.牙炎症牙炎症口腔状细胞癌的癌症.牙周炎是指牙周炎的一种疾病.

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