深度学习来预测未来的地理缩的增长从底部自光学
Anish Salvi1, Julia Cluceru1, Simon S Gao1
1Genentech, Inc., South San Francisco, California.
Ophthalmology science
|January 6, 2025
概括
使用基底自光 (FAF) 图像的深度学习模型可以预测地理缩 (GA) 的1年增长区域 (ROG). 最好的模型利用基线和6个月后的FAF图像进行准确的GA病变扩大预测.
科学领域:
- 眼科医生 眼科 眼科
- 医疗成像医学成像
- 人工智能的人工智能
背景情况:
- 地理缩 (GA) 的进展影响视觉结果.
- 预测GA的生长区域 (ROG) 对患者管理至关重要.
- 底部自光成像 (FAF) 为GA评估提供了有价值的数据.
研究的目的:
- 开发和评估深度学习模型,用于预测GA病变的1年ROG.
- 使用FAF图像预测GA损伤扩张.
- 评估不同的FAF基于图像的深度学习方法对GA ROG预测的有效性.
主要方法:
- 临床试验中的FAF图像的回顾性分析.
- 使用2D U-Net架构开发三种深度学习模型.
- 培训和验证使用来自597名患者的数据集,按病变特征分层.
主要成果:
- 使用基线和6个月FAF图像的模型在预测1年的GA ROG方面表现出卓越的表现.
- 获得了高的子得分 (0.73训练,0.68验证,0.70测试) 和强大的R2 (0.77,0.53,0.79) 和r2 (0.83,0.61,0.79) 相对关系.
- 在训练,验证和测试集中观察到一致的性能趋势.
结论:
- 分析FAF图像的深度学习模型显示了预测1年的GA ROG的巨大潜力.
- 这种预测能力可以帮助临床试验决策,并为治疗策略提供信息.
- 与人工智能相结合的FAF成像为管理地理缩提供了一个有希望的途径.
更多相关视频
相关概念视频
01:15Depth Perception and Spatial Vision
Depth perception is the ability to perceive objects three-dimensionally. It relies on two types of cues: binocular and monocular. Binocular cues depend on the combination of images from both eyes and how the eyes work together. Since the eyes are in slightly different positions, each eye captures a slightly different image. This disparity between images, known as binocular disparity, helps the brain interpret depth. When the brain compares these images, it determines the distance to an object.
01:26Influence of Earth's Curvature and Atmospheric Refraction on Leveling
During leveling, the Earth's curvature and atmospheric refraction introduce deviations in the line of sight from a true horizontal reference. When the line of sight is leveled, it remains perpendicular to the plumb line only at a single point. Beyond this, it deviates due to the Earth’s curvature, represented by the correction C. For a sight distance D, the deviation can be derived using the relationship:This relationship shows that the deviation increases quadratically with distance. Over a...
01:25Methods of Obtaining Topography
Topography involves measuring and mapping land elevations, natural features, and artificial structures to create accurate representations of the terrain. Topographic surveying relies on traditional and modern methods, each with distinct advantages and limitations.Traditional Surveying Methods:Transit stadia surveys and plane table surveys were widely used traditional surveying methods. These techniques relied on instruments like theodolites and stadia rods for measuring distances and angles,...
01:29Levels of Use of a GIS
Geographic Information Systems (GIS) operate across three levels of application, each representing an increasing degree of complexity: data management, analysis, and prediction. These levels reflect the expanding functionality and versatility of GIS technology in handling spatial data for diverse purposes.Data ManagementAt its foundational level, GIS serves as a tool for data management, enabling the input, storage, retrieval, and organization of spatial data. This level is often employed in...