咖啡因补充剂,炎症和肝硬化患者的肝功能:一个随机的,安慰剂控制的临床试验
Seyed Ali Abbas-Hashemi1, Zahra Yari2, Behzad Hatami3
1Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Science, Tehran, Iran.
Heliyon
|January 6, 2025
概括
咖啡因补充剂显著改善了肝纤维化,并减少了肝硬化患者的炎症. 每天摄入400毫克咖啡因导致更好的肝功能标志物和减少炎症生物标志物.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 临床营养学 临床营养学
- 药理学 药理学是指药理学的学科.
背景情况:
- 肝硬化是一种严重的肝病,其特征是炎症和肝功能受损.
- 目前的肝硬化治疗策略往往侧重于减缓疾病进展和管理并发症.
- 对肝硬化治疗的新型治疗剂的探索对于改善患者的治疗结果至关重要.
研究的目的:
- 研究咖啡因补充剂在治疗炎症和改善肝硬化患者肝功能方面的疗效.
- 评估每日咖啡因摄入量对肝纤维化和肝硬化患者的炎症标志物的影响.
主要方法:
- 一项随机,双盲,安慰剂对照试验与50名被诊断患有肝硬化的患者进行.
- 参与者被分配每天接受400毫克咖啡因或安慰剂,持续8周.
- 在整个研究过程中,关键的肝功能测试,炎症生物标志物和纤维化得分都受到监测.
主要成果:
- 与安慰剂相比,咖啡因补充剂显著降低了AST,血小板计数和前血红蛋白时间 (PTT).
- 在咖啡因组观察到炎症生物标志物的显著下降 (p <0.05).
- 在服用咖啡因补充剂八周后,肝脏指数 (包括APRI,纤维化-4分数和MELD分数) 显著改善.
结论:
- 每天400毫克咖啡因补充剂显示出在肝硬化患者中改善肝纤维化的显著潜力.
- 咖啡因的摄入有效地减少了与肝病进展相关的关键炎症因素.
- 这些发现表明咖啡因是治疗肝硬化的可行的辅助疗法,需要进一步调查.
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