血清加勒-3水平的升高与高血压患者的内皮功能障碍和心血管事件有关
Hui-Sheng Wang1, Bang-Gee Hsu2, Ji-Hung Wang1,3,4
1Division of Cardiology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Heliyon
|January 6, 2025
概括
较高的加勒-3 (Gal-3) 水平与高血压患者的血管反应能力低下和心血管事件增加有关. 这表明Gal-3可能在高血压引起的内皮功能障碍中发挥作用.
科学领域:
- 心血管医学 心血管医学
- 内分泌学 在内分泌学.
- 炎症研究 炎症研究
背景情况:
- 内皮功能障碍是心血管并发症的前体.
- 加勒-3 (Gal-3) 与炎症性心脏病有关.
- 需要澄清Gal-3在高血压相关的内皮功能障碍中的特定作用.
研究的目的:
- 在高血压患者中,研究血清中加勒-3 (Gal-3) 水平与内皮功能障碍之间的关联.
- 评估该队列中Gal-3水平与长期心血管结果之间的关系.
主要方法:
- 招募了120名高血压患者,并进行了为期7年的心血管结果监测.
- 血清Gal-3水平使用酶相关免疫吸收试验量化.
- 血管反应指数 (VRI) 通过数字热监测进行评估.
主要成果:
- 在12名患者中观察到较差的血管反应,在57名患者中观察到中等反应,在51名患者中观察到良好的反应.
- 与较差的内皮功能障碍相关的因素包括年龄,高胆固醇和LDL,较低的EGFR和较高的Gal-3水平.
- 较高的Gal-3水平与较低的VRI相关,并且与7年内心血管事件增加有关.
结论:
- 血清Gal-3水平升高与高血压患者的内皮功能障碍有关.
- 较高的Gal-3水平预测高血压患者的不良心血管事件.
- 加勒-3可能是高血压诱导的内皮功能障碍的病理生理学的一个重要因素.
相关概念视频
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
37
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
37
Hypertension and Regulation of Blood Pressure
1.8K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
1.8K
Proteoglycans
3.8K
Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
3.8K


