视力受损的格劳科马患者患抑郁症的风险:一项全国性的队列研究
Sheng-Min Wang1, Younhea Jung2, Kyungdo Han3
1Department of Psychiatry, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Heliyon
|January 6, 2025
概括
主要开角绿眼明显增加了抑郁症的风险,特别是在视力受损. 这种风险在男性和伴随疾病较少的人群中较高.
科学领域:
- 眼科医生 眼科 眼科
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 主要开角青光眼 (POAG) 是不可逆转失明的主要原因.
- 抑郁症是一种常见且严重的心理健康状况,对公共健康有重大影响.
- 需要进一步调查POAG,视力障碍和抑郁风险之间的关系.
研究的目的:
- 调查原发性开角青光眼与患抑郁症的风险之间的关联.
- 为了检查视力障碍如何与玻璃眼结合,影响抑郁症风险.
- 为了确定改变这种关联的特定的人口或临床因素.
主要方法:
- 一项全国性的基于人口的队列研究,利用来自韩国国家健康信息数据库和国家残疾登记处的数据.
- 包括2009年查的3,680,570名个人,并对新的抑郁症诊断进行随访.
- 使用多变量调整的Cox比例危险模型进行分析,控制基线特征和并发症.
主要成果:
- 患有青光眼的人患抑郁症的风险增加了1.085倍 (调整HR:1.085,95%CI:1.050-1.121).
- 抑郁症的风险随着格劳科马患者视力障碍的存在和严重性而升级 (视力障碍和严重视力障碍的调整HR值分别为1.164和1.207).
- 青光眼和抑郁症之间的关联在男性和伴随性疾病较少的人群中更为明显 (查尔森伴随性疾病指数<3).
结论:
- 主要的开角玻璃眼是发展抑郁症的一个独立风险因素.
- 同时的视力障碍加剧了青光眼患者抑郁症的风险.
- 男性和伴随性疾病较少的人在新出现的抑郁症上经历了更大的玻璃眼和视力障碍的影响.
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