对表观遗传衰老的多基因风险和不良生活经历相互作用,在种族/种族多样化的样本中预测青少年抑郁症的增长
Kit K Elam1, Jinni Su2, Weisiyu Abraham Qin1
1Department of Applied Health Science, School of Public Health, Indiana University, Bloomington, IN, United States.
Frontiers in psychiatry
|January 6, 2025
概括
不利的生活事件加剧了对表观遗传衰老的遗传倾向,增加了青少年患抑郁症的风险. 这突显了环境因素如何与青少年心理健康中的遗传因素相互作用.
科学领域:
- 青少年精神病学 青少年精神病学
- 遗传学 遗传学 是一个
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 研究尚未探索环境风险,弹性和遗传倾向对表观遗传衰老和青少年抑郁症的综合影响.
- 由GrimAge表示的表观遗传衰老是一种生物标志物,可能反映累积的环境暴露,并影响健康结果.
研究的目的:
- 调查不良生活事件和家长的接受是否缓解了GrimAge遗传倾向与青春期早期表观遗传衰老和抑郁症状轨迹之间的关联.
- 检查这些跨不同种族子群体 (欧洲裔美国人,非洲裔美国人,拉丁人) 的相互作用.
主要方法:
- 利用了青少年大脑发育研究 (N = 11,875) 的数据.
- 计算了GrimAge的多基因分数,并采用增长混合模型来分析10/11至12/13年龄段的抑郁症状轨迹.
- 对欧洲裔美国人,非洲裔美国人和拉丁裔参与者分别进行分析.
主要成果:
- 在欧洲裔美国人和非洲裔美国人亚组中,不良生活事件显著缓解了GrimAge多基因分数和抑郁症轨迹之间的关系.
- 具有更高遗传风险和更大暴露于不良生活事件的个体显示出属于更高抑郁轨迹的可能性增加.
结论:
- 对表观遗传衰老 (GrimAge) 的遗传贡献代表了青少年抑郁症的诊断.
- 不利的生活事件在加剧青春期患抑郁症的遗传倾向方面发挥着关键作用.
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