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部分囊切除术作为患有病理性膀侵袭的结直肠癌患者的手术选择:一个原始的回顾性研究

Bing Lan^1,2, Rui Luo^1,2, Yang Li^1,2

¹Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

Therapeutic advances in gastroenterology

|January 6, 2025

概括

在接受囊切除术的结直肠癌 (CRC) 患者中,病理性膀侵袭可能不会显著影响存活率. 对这些患者来说,部分囊切除术可以提供与全囊切除术相似的结果.

科学领域:

在瘤学瘤学.
手术瘤学手术瘤学
泌尿器科泌尿器科泌尿器科泌尿器科

背景情况:

有限的研究存在于结直肠癌 (CRC) 与膀侵袭.
膀侵袭性CRC的囊切除术后的生存结果尚未得到充分研究.
最佳的手术方法,部分或全囊切除术,仍在争论中.

研究的目的:

为了评估病理性膀侵袭对长期瘤预后的影响,在囊切除术后的CRC患者.
为了比较患有病理性膀侵袭和没有病理性膀侵袭的患者之间的生存结果.

主要方法:

对105名患有膀侵袭的CRC患者进行了回顾性队列研究,这些患者接受了部分或全囊切除 (2012-2020年).
收集的数据包括手术和病理信息.
患者根据病理性膀侵袭状态进行分组,并根据3年总生存期 (OS) 和无复发生存期 (RFS) 进行比较.
多光子成像用于评估样本子集中的原特性.

主要成果:

病理性膀侵袭在48%的患者中得到证实.
在有病理性膀侵袭和没有病理性膀侵袭的患者之间,在3年后的OS或RFS中没有观察到显著差异.
在不同组中,复发率 (局部,静脉内) 并没有显著差异.
远程转移被确定为OS和RFS的独立风险因素.
通过多光子成像分析的原特性没有显示出统计差异.

结论:

病理性膀侵袭可能对CRC患者的细胞切除术后存活率的影响小于临床假设.
在病理性膀侵袭的情况下,部分囊切除可能会提供与全囊切除相似的生存率.
需要进一步的研究,以充分阐明膀入侵在CRC中的影响.

关键词:

膀的入侵膀的入侵结肠直肠癌是什么意思诊断诊断诊断诊断诊断诊断一部分囊切除术治疗治疗治疗治疗治疗治疗瘤预后瘤预后

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