在COVID-19大流行期间,胃肠道出血相关死亡率增加
Xu Gao1, Yee Hui Yeo2, Fan Lv3
1Division of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Therapeutic advances in gastroenterology
|January 6, 2025
概括
胃肠道出血 (GIB) 死亡率下降到2019年,然后在大流行期间升,特别是在年轻男性中. 到2023年,过度的GIB死亡问题将得到解决,上方的GIB趋势会恶化,下方的GIB趋势会逆转.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 胃肠病学 胃肠病学
背景情况:
- 胃肠道出血 (GIB) 对健康构成重大负担.
- 国家一级GIB死亡率的时间模式仍未得到充分研究.
研究的目的:
- 分析美国GIB相关死亡率的年度和月度趋势.
- 为了确定GIB死亡率的时间模式和人口变化.
主要方法:
- 使用国家生命统计系统数据库 (2010-2023年).
- 计算了年龄标准化的死亡率,并进行了结点回归来进行趋势分析.
- 使用预测建模来评估与GIB相关的过度死亡率.
主要成果:
- 从2010年至2019年,GIB死亡率下降,随后在COVID-19大流行期间,在2021年出现过度死亡率峰值.
- 月度趋势显示与变种爆发相关的尖峰;到2023年,过度死亡率将得到解决.
- 年轻男性 (19-44岁) 经历了最高的过度死亡率;上部GIB趋势恶化,而下部GIB趋势反转.
结论:
- GIB死亡率趋势显示了与流行病有关的显著过剩,此后已经得到解决.
- 确定了易受伤害的子群体,特别是年轻男性,在疫情期间受到不成比例的影响.
- 该研究强调了由公共卫生危机影响的GIB死亡率的动态性质.
相关概念视频
Esophageal Varices-II: Clinical Features and Management
23
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
23
Inflammatory Bowel Disease I: Ulcerative Colitis
91
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
91
Esophageal Varices-I: Introduction
45
Esophageal varices are dilated, tortuous veins which are found mainly in the submucosa of the lower esophagus but which may also appear higher up or extend into the stomach. They develop due to increased pressure in the portal venous system, often as a result of liver cirrhosis. This condition scars and damages the liver, impeding normal blood flow through the portal vein. To compensate, blood seeks alternative pathways, forming fragile new vessels (varices) in the esophagus and stomach. These...
45
Inflammatory Bowel Disease II: Crohn's Disease
122
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
122
Peptic Ulcer Disease I: Introduction
81
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
81
Gastritis III: Clinical Manifestations and Management
90
The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
90


