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Updated: May 7, 2025

Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood
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Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood

Published on: February 6, 2018

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携带全长的人类免疫球蛋白位点的小鼠通过兰巴达光链产生抗原特异的人类抗体

Kazuto Shimoya1, Takashi Moriwaki2,3, Kanako Kazuki2

  • 1Department of Chromosome Biomedical Engineering, Integrated Medical Sciences, Graduate School of Medical Sciences, Tottori University, 86 Nishi-cho, Yonago, Tottori 683-8503, Japan.

iScience
|January 6, 2025
PubMed
概括

研究人员开发了能够产生人类兰巴达抗体的基因工程小鼠,绕过了对抗体人性化的需求. 这一突破为开发被忽视的兰巴抗体疗法提供了一个新的平台.

关键词:
生物科学研究方法 生物科学研究方法基因工程是一种基因工程.免疫反应的免疫反应.

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相关概念视频

Hybridoma Technology01:31

Hybridoma Technology

Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
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