唾液前炎症媒介与2型糖尿病的差异关联:一个网络元分析
Ying Zhang1, Lijuan Li1, Yunsong Guo2
1Endocrinology Department, The People's Hospital of Yubei District of Chongqing city, Chongqing 401120, China.
Iranian journal of public health
|January 6, 2025
概括
唾液分析显示,2型糖尿病 (T2DM) 患者的炎症调解因子增加,特别是白内素-6. 这些唾液标记物可能有助于监测与T2DM相关的口腔健康变化.
科学领域:
- 口腔医学是指口腔医学.
- 生物标志物 生物标志物
- 糖尿病研究研究 糖尿病研究
背景情况:
- 唾液化合物作为2型糖尿病 (T2DM) 口腔健康问题的潜在诊断标志物.
- 在T2DM患者中,口腔并发症很常见.
研究的目的:
- 进行元分析,评估与健康对照组相比,T2DM患者的唾液样本.
- 确定与T2DM和患者特征相关的特定唾液生物标志物.
主要方法:
- 一个系统的对13项观察性研究的元分析 (519名T2DM患者,356名对照) 发表到2023年11月.
- 搜索了包括PubMed,EMBASE,Scopus,Cochrane图书馆和Web of Science在内的主要数据库.
- 使用预后研究质量 (QUIPS) 工具评估偏差风险;用于标准化平均差异 (SMD) 的随机效应模型.
主要成果:
- 与健康人群相比,患有T2DM的患者表现出明显更高的唾液前炎症媒介水平 (SMD: 1.66;P<0.01).
- 在T2DM患者中观察到高水平的互白素-6 (IL-6) (SMD: 1.33; P<0.05) 和互白素-8 (IL-8) (SMD: 0.92; P<0.13).
- 网络分析将唾液因子与患者特征联系起来:男性的瘤亡因子,女性的IL-8和HbA1c,以及C反应蛋白与禁食血葡萄糖和年龄.
结论:
- 在T2DM患者中,唾液IL-6水平升高,可以作为监测口腔健康变化的有价值标志物.
- 网络分析有效地确定了特定的唾液成分与患者人口统计学和临床因素之间的关联.
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