IL-12家族细胞因子和自身免疫性疾病:一个潜在的治疗标?
Xiaoyu Cui1,2, Wu Liu1, Hanxue Jiang1
1Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, 100010, China.
Journal of translational autoimmunity
|January 6, 2025
概括
细胞因子IL-12家族,包括IL-12和IL-23,是T细胞对自身免疫性疾病反应的关键调节者. 准这些细胞因子显示出新型自身免疫疗法的前景.
科学领域:
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 交联素-12 (IL-12) 细胞因子家族,包括IL-12,IL-23,IL-27,IL-35和IL-39,在免疫系统调节中发挥着重要作用.
- 在各种自身免疫性疾病中观察到这些细胞因子的异常表达,影响疾病发病和进展.
研究的目的:
- 审查主要IL-12家族成员的生理功能和相互作用.
- 讨论IL-12家族细胞因子在自身免疫性疾病的发病过程中的参与.
- 总结针对IL-12和IL-23.3的治疗方法的临床进展.
主要方法:
- 关于IL-12家族细胞因子生理功能的文献综述.
- 分析IL-12家族成员在自身免疫性疾病模型中的作用.
- 对针对单克隆抗体的IL-12和IL-23的临床试验数据的摘要.
主要成果:
- IL-12家族细胞因子通过共享的子单元调节T细胞激活和分化.
- 失调IL-12家族细胞因子表达有助于自身免疫性疾病.
- 针对IL-12和IL-23亚单元的单克隆抗体正在成为治疗选择.
结论:
- IL-12细胞因子家族在自身免疫性疾病中被破坏的免疫平衡中发挥着关键作用.
- 了解每个IL-12家族成员的特定角色为治疗提供了机会.
- 针对IL-12和IL-23的向疗法显示出治疗自身免疫性疾病的临床潜力.
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