在366,484个正常喷射分数个体中,心脏尺寸小和过早死亡
Stephanie J Rowe1,2,3,4, Elizabeth D Paratz1,2,3,4, Louise Fahy1,2,3
1HEART Lab, St Vincent's Institute of Medical Research, Fitzroy, Australia.
JACC. Advances
|January 6, 2025
概括
在正常左心室喷射率 (LVEF) 个体中,心脏尺寸小与更高的过早死亡率有关. 这种增加的风险在女性和高正常LVEF的女性中尤为明显.
科学领域:
- 心脏病学 心脏病学
- 心声回声扫描 (Echocardiography) 是一种心声回声扫描.
- 公共卫生 公共卫生
背景情况:
- 保存的左心室喷射分数 (LVEF) 在许多心脏疾病中很常见.
- 保存LVEF中的小心室尺寸与功能能力的降低有关.
- 小心室尺寸对保存LVEF的临床结果的影响尚不清楚.
研究的目的:
- 为了调查小心尺寸和早逝率之间的关联.
- 为了分析一个大型的,多中心的成年患者队列,使用跨胸腔心声学.
- 为了确定左心室终端透缩体积 (LVEDV) 和5年死亡率之间的关系.
主要方法:
- 分析了366,484名LVEF≥50%的个人 (包括279,442名LVEF≥60%).
- 按性别和四分位数对 LV 末端透气体体积 (LVEDV),索引 LVEDV (LVEDVi) 和 LV 末端透气体直径进行分层.
- 通过与国家死亡指数的联系对大约200万人年进行死亡率评估.
主要成果:
- 最小的心脏大小四分位数与更高的5年全因死亡率有关,即使在年龄调整后也是如此.
- 最小的LVEDVi四分位数显示5年全因死亡率增加了14-18%,高正常LVEF的影响更大.
- 在LV腔大小和全因死亡率之间观察到U形关系;LVEDVi最小的女性心血管死亡率更高,特别是LVEF≥60%.
结论:
- 小心室尺寸与正常LVEF的个体的死亡率增加有关.
- 增加的死亡风险对女性和LVEF较高的人来说尤为重要.
- 这些发现突显了心室大小在保存的LVEF中的预后重要性.
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