评估Posaconazole和Voriconazole在软上的抗真菌作用
Madhurima Sharma1, Taniya Bhatia1, Rohit Sharma2
1Prosthodontics, Teerthanker Mahaveer Dental College and Research Centre, Moradabad, IND.
Cureus
|January 6, 2025
概括
这项研究发现,将抗真菌药物纳入软中显著提高了它们抑制真菌生长的能力. 与voriconazole相比,Posaconazole在与软结合时表现出优异的抗真菌活性.
科学领域:
- 生物材料科学 生物材料科学
- 菌类学 菌类学是指菌类学.
- 牙科材料 牙科材料
背景情况:
- 软分发力,但可以庇护Candida物种,造成风险,特别是对于免疫力低下的个体.
- 软上的真菌积累是一个临床挑战.
- 抗真菌剂正在探索减轻牙科材料中的微生物生长.
研究的目的:
- 为了评估和比较软内与波萨可纳和沃里可纳结合的抗真菌活性.
- 为了评估抗真菌装载软对抗真菌长期生长的有效性.
主要方法:
- 一个单一的软料材料与波萨可纳和沃里可纳相结合.
- 样本被准备好,浸泡在蒸水中,并测试其抗真菌活性.
- 在第1,10和20天测量了增长抑制区域.
主要成果:
- 在两组中观察到增长抑制区域的统计学上显著差异.
- 含有波萨康纳 (II组) 的软层表现出最大的抑制区域,其次是含有伏利康纳 (III组) 的软层.
- 随着时间的推移,抗真菌活性增加,在20日观察到的最大抑制值.
结论:
- 将波萨康纳和沃里康纳与软结合起来,显著改变了它们的抗真菌特性.
- 与沃里可纳和对照软相比,装有波萨可纳的软显示出更高的抗真菌功效.
- 这些发现表明,在使用抗真菌修饰软的患者中,有可能改善感染控制.
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