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针对uORF的固体阻断抗意义寡核酸没有可复制地增加RNASEH1的表达

Nina Ahlskog1,2, Nenad Svrzikapa1,3,4, Rushdie Abuhamdah1,2

  • 1Department of Paediatrics, University of Oxford, Headington, Oxford OX3 7TY, UK.

Molecular therapy. Nucleic acids
|January 6, 2025
PubMed
概括

针对上游开放阅读框架 (uORFs) 的绝缘块反意义寡核酸 (ASO) 被研究了它们增加蛋白质表达的能力. 被测试的ASO未能提高蛋白质水平,有时甚至会降低蛋白质水平.

关键词:
MT:寡核酸:治疗方法和应用.在RNASEH1中使用.反感的寡核化物.绝缘区块 ASO 的绝缘区块.在 uORF 的情况下.上游开放的阅读框架.

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