生物标志物的诊断性能,以区分活跃结核病和潜伏结核病:一个系统的审查和贝叶斯网络的元分析
Ji Hun Jeong1, Sung Ryul Shim2,3, Sangah Han4
1Department of Laboratory Medicine, Daejeon Eulji Medical Center, Eulji University, Daejeon, Republic of Korea.
Frontiers in microbiology
|January 6, 2025
概括
在用潜伏抗原刺激后,介质素-2 (IL-2) 水平在区分活动性结核病 (TB) 和潜伏性结核病感染 (LTBI) 方面表现有前途. 这一发现为准确的结核病诊断提供了潜在的新生物标志物.
科学领域:
- 医学诊断 医学诊断 医学诊断
- 传染性疾病 传染性疾病
- 生物标志物发现发现
背景情况:
- 活跃结核病 (TB) 诊断依赖PCR和培养,但培养需要很长的周转时间.
- 干扰素-释放试验 (IGRA) 用于结核病和潜伏结核病感染 (LTBI),但不能可靠地区分它们.
- 精确区分活跃结核病和长期结核病对于有效的治疗和公共卫生管理至关重要.
研究的目的:
- 系统地审查和元分析各种生物标志物的诊断性能,以区分活性结核病与LTBI.
- 确定最有效的生物标志物来区分结核病和LTBI.
主要方法:
- 我们对PubMed-Medline,EMBASE,Cochrane图书馆和科学网进行了全面的搜索.
- 对符合条件的研究进行了系统审查和网络元分析 (NMA),评估生物标志物的诊断价值.
- 通过使用QUADAS-2工具评估研究质量,并遵循PRISMA指南.
主要成果:
- 系统性审查包括了159份报告,其中58份报告对元分析做出了贡献 (9,291名参与者).
- 在用潜伏抗原进行刺激后,测量介质素-2 (IL-2) 显示出灵敏度,特异性,正预测值和负预测值的最高概率比率.
- 针对IL-2的具体值是:灵敏度9.46,特异性18.5,正预测值11.30,负预测值9.61.
结论:
- 在用潜伏抗原刺激后,介质素-2 (IL-2) 水平代表了区分活跃结核病 (TB) 和潜伏结核病感染 (LTBI) 的有希望的生物标志物.
- 这一发现可能会导致改善结核病的诊断策略.
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