在轻度与年龄相关的听力损失中,网络组织受损
Zhaopeng Tong1,2, Chunhua Xing3, Xiaomin Xu3
1Department of Otolaryngology Sun Yat-sen Memorial Hospital Sun Yat-sen University Guangzhou China.
MedComm
|January 6, 2025
概括
与年龄相关的听力损失 (ARHL) 破坏了大脑的连接,特别是在默认模式网络 (DMN) 中. 这种神经功能障碍与老年人的认知能力下降有关.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 医疗成像医学成像
背景情况:
- 年龄相关听力损失 (ARHL) 是老年人常见的一种神经退行性疾病.
- 在ARHL和认知衰退之间的关系仍然不太清楚.
研究的目的:
- 研究ARHL诱导的功能性大脑网络连接 (静态和动态) 的障碍.
- 探索全球网络切换的变化及其与ARHL患者认知表现的关联.
主要方法:
- 使用了休息状态功能磁共振成像 (fMRI).
- 分析技术包括组空间独立组件分析,滑动窗口分析,图形理论,多层网络和相关性分析.
- 该研究包括66名ARHL患者和54名健康对照.
主要成果:
- 在默认模式网络 (DMN) 中,ARHL与静态和动态功能网络连接 (sFNC/dFNC) 的降低有关.
- 在患有ARHL的人群中,DMN和中央执行,突出 (SN) 和视觉网络之间观察到增加的sFNC/dFNC.
- 在ARHL中,在DMN和听觉网络 (AUN) 之间以及在SN和AUN之间,dFNC的变异性减少.
- 患有ARHL的个体表现出较低的全球网络切换率,特别是在DMN内.
- 在DMN中的干扰与执行功能和记忆力受损相关.
结论:
- ARHL导致大脑功能连接和网络动态的显著改变.
- 在DMN中的补偿性变化可能会损害信息处理,加速大脑衰老,并导致认知能力下降.
- 这些发现突出了感官损失对衰老中的认知健康的神经影响.
相关概念视频
Hearing
51.1K
When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
51.1K
Auditory Pathway
4.5K
Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...
4.5K
Olfactory Receptors: Location and Structure
8.5K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
8.5K
The Cochlea
43.8K
The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
43.8K
Unrenewable Cells
2.3K
In humans, the photoreceptor cells of the eye and sensory hair cells of the ear lack stem cells. These cells are thus unrenewable and cannot be replaced when they are damaged or destroyed.
Photoreceptors
The retina is composed of several layers and contains specialized cells called photoreceptors. The photoreceptors (rods and cones) change their membrane potential when stimulated by light energy. There are two types of photoreceptors—rods and cones—which differ in the shape of...
Photoreceptors
The retina is composed of several layers and contains specialized cells called photoreceptors. The photoreceptors (rods and cones) change their membrane potential when stimulated by light energy. There are two types of photoreceptors—rods and cones—which differ in the shape of...
2.3K
Hair Cells
39.2K
Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
39.2K


