在乳腺癌中与癌症治疗相关的心脏功能障碍的风险分层的左心室椎复杂性
Hesong Shen1, Qian Xu2, Chunrong Tu1
1Department of Radiology Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital Chongqing China.
MedComm
|January 6, 2025
概括
使用左心室轨道骨折维度 (LVTFD) 的新得分有效预测乳腺癌患者的癌症治疗相关心脏功能障碍 (CTRCD). 与现有方法相比,这种基于LVTFD的得分提供了更好的风险分层.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 医疗成像医学成像
背景情况:
- 与癌症治疗相关的心脏功能障碍 (CTRCD) 对接受 antracyclines 的乳腺癌患者构成重大风险.
- 准确的基线风险分层对于管理CTRCD至关重要.
- 心脏MRI中的左心室轨道骨折尺寸 (LVTFD) 反映了心肌复杂性和心血管风险.
研究的目的:
- 开发和验证一种新型的风险评分系统,用于基线CTRCD分层在乳腺癌患者治疗与Anthracyclines.
- 评估基于LVTFD的评分与心力衰竭协会-国际心脏瘤学会 (HFA-ICOS) 的评分的表现.
主要方法:
- 使用考克斯模型来导出和验证一个新的得分,包括LVTFD,年龄,高血压,先前的心血管疾病和最大的顶端碎形尺寸.
- 这项研究包括370名乳腺癌患者,其中73人患有CTRCD.
- 使用C指数进行性能比较.
主要成果:
- 与HFA-ICOS得分相比,基于LVTFD的得分在分层CTRCD风险方面表现优越,无论是在导出 (C指数0.834对0.642) 和验证队列 (C指数0.834对0.633) 中.
- 基于LVTFD的得分准确地分层了CTRCD风险,而HFA-ICOS得分没有.
- 最大顶端分形维度是预测得分的关键组成部分.
结论:
- 基于LVTFD的得分是一种有价值的替代工具,用于在接受 antracycline治疗的乳腺癌患者中对CTRCD的基线风险分层.
- 将LVTFD整合到风险评估中可以提高该患者群体心脏功能障碍的预测.
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