2010年至2020年在沙特阿拉伯使用阿片类药物和NSAID的模式
Abdullah U Althemery1, Mohammed Alsubaie1, Hamoud Alharbi2
1Department of Clinical Pharmacy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia.
Journal of psychoactive drugs
|January 6, 2025
概括
沙特阿拉伯的阿片类药物和NSAID使用量在2019年达到顶峰,其中帕拉西托马尔是最常被处方的. 2020年,特拉马多尔处方激增,止痛药的成本大幅波动.
科学领域:
- 药理学 药理学是指药理学的学科.
- 卫生经济学 卫生经济学
- 公共卫生 公共卫生
背景情况:
- 全球止痛药的使用量有所增加,处方药的滥用明显增加,特别是涉及阿片类药物.
- 阿片类药物和非类固醇抗炎药物 (NSAIDs) 广泛用于治疗疼痛,因此需要了解它们的使用模式和相关成本.
研究的目的:
- 分析2010年至2020年沙特阿拉伯阿片类药物和NSAIDs的利用和支出趋势.
- 为了确定最常被处方的止痛药,并观察十年来它们的处方模式的变化.
主要方法:
- 使用沙特阿拉伯利雅得两个主要医院的数据进行了描述性的时间序列分析.
- 住院患者,门诊患者和急诊室的处方数据从2010年到2020年收集.
- 包括的止痛药包括赛莱科西布,二甲,易布洛芬,洛诺西卡姆,美芬胺酸,,和特拉马多尔.
主要成果:
- 总共有48106个止痛药处方被发行. 所有研究的阿片类药物和NSAIDs的峰值利用发生在2019年.
- 降醇占所有处方的29.33%,但特拉马多尔处方在2020年是最高的 (2,798处方).
- 从2012年到2019年,每处方单位的平均成本下降,然后在2020年急剧增加,从SAR 0.87到SAR 4.50.
结论:
- 调查结果强调了沙特阿拉伯十年来止痛药处方模式和成本的重大变化.
- 该研究为医疗保健政策提供了宝贵的见解,旨在优化止痛治疗质量和患者护理.
- 监测阿片类药物和NSAID的使用对于解决处方药滥用和确保成本有效的疼痛管理策略至关重要.
相关概念视频
Opioid Analgesics: Synthetic and Semisynthetic Opioids
163
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
163
Analgesia and Pain Management
390
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
390
Opioid Analgesics: Morphine and Other Natural Cogeners
132
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
132
Prescription, Nonprescription and Orphan Drugs
639
Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
639
Drug Classes and Categories
1.8K
Drugs can be classified according to their chemical composition or their intended therapeutic application. For instance, anti-infective agents that possess the ability to eliminate pathogens or suppress their growth and reproduction can be grouped based on the organisms they target or their chemical structure. Furthermore, drugs can be divided into prescription, nonprescription, or controlled substances. Prescription medications, such as antibiotics, require oversight from a licensed healthcare...
1.8K
Opioid Receptors: Overview
305
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
305


