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Updated: Jun 3, 2025

Laser Capture Microdissection of Enriched Populations of Neurons or Single Neurons for Gene Expression Analysis After Traumatic Brain Injury
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Laser Capture Microdissection of Enriched Populations of Neurons or Single Neurons for Gene Expression Analysis After Traumatic Brain Injury

Published on: April 10, 2013

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单细胞RNA测序揭示了创伤性脑损伤后神经发生障碍背后的分子特征

Cong Liu1,2, Fang-Hong Shao1,3, Xuan-Cheng He1,4,5

  • 1Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.

Glia
|January 6, 2025
PubMed
概括

创伤性脑损伤 (TBI) 通过减少特定的神经干细胞 (NSC) 亚群来损害神经发生. 在这些细胞中恢复DLX2基因促进神经元分化,为TBI恢复提供了潜在的治疗策略.

关键词:
在 DLX2 的情况下.状状体分化的差异化神经干细胞的神经干细胞神经发生神经发生.创伤性脑损伤是一种创伤性脑损伤

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Stereotactic Atlas-Guided Laser Capture Microdissection of Brain Regions Affected by Traumatic Injury

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Isolation of Region-specific Microglia from One Adult Mouse Brain Hemisphere for Deep Single-cell RNA Sequencing09:49

Isolation of Region-specific Microglia from One Adult Mouse Brain Hemisphere for Deep Single-cell RNA Sequencing

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Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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