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刺激性肠综合征的发育起源:系统性审查和元分析
Makenna B Lenover Moyer1, Krishangi Jasani1, Alexandra B Waldman2
1Department of Anthropology, The Pennsylvania State University, University Park, Pennsylvania, USA.
概括
童年创伤和患有刺激性肠综合征 (IBS) 的家庭病史显著预测成人IBS. 这些发现强调了早期生活经验和遗传学在IBS发展中的关键作用.
科学领域:
- 胃肠病学 胃肠病学
- 发展心理学 发展心理学
- 流行病学 流行病学
背景情况:
- 健康和疾病的发育起源 (DOHaD) 框架将慢性疾病与生命早期的暴露联系起来.
- 刺激性肠综合征 (IBS) 研究主要集中在成人因素上,对儿童影响的调查有限.
- 新出现的证据表明表观遗传因素可能导致IBS,需要探索发育途径.
研究的目的:
- 应用终身方法来研究IBS病因.
- 系统地审查和分析有关成人IBS儿童风险因素的证据.
- 为了确定IBS的潜在发展起源.
主要方法:
- 根据MOOSE和PRISMA协议进行了一次系统的文献审查.
- 从1970年到2024年4月发表的研究包括检查产前,儿童和青少年IBS风险因素.
- 使用随机效应模型对27项已识别的研究的数据进行了元分析.
主要成果:
- 成年IBS的显著儿童风险因素包括家庭病史 (合并OR 2.17) 和任何童年创伤 (合并OR 1.61).
- 身体和性创伤被确定为最强烈的创伤预测因素.
- 没有发现母乳养和剖腹产是显著的危险因素.
结论:
- 创伤性童年经历和IBS家族史强烈预测IBS.
- 经过证明的环境和遗传组件表明了儿童时期潜在的基因环境相互作用.
- 需要进一步的初级研究来阐明IBS的发育起源.
关键词:
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