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肠移植后儿童的长期生长和营养结果
Ahmad Miri1, Angela K Iverson2, Nathan Law3
1Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Journal of pediatric gastroenterology and nutrition
|January 6, 2025
概括
肠移植 (ITx) 改善了儿童的长期线性生长. 然而,诸如发育迟缓和口腔损伤等因素可能会延长移植后需要输液管养的时间.
科学领域:
- 儿科手术 儿科手术
- 移植医学 移植医学
- 胃肠病学 胃肠病学
背景情况:
- 肠道移植 (ITx) 是患有肠道衰竭和亲肠营养 (PN) 依赖症的儿童的可行选择.
- 在ITx后,长期关于生长和营养状况的结果对于患者管理至关重要.
研究的目的:
- 评估儿科ITx接受者的长期生长和营养结果.
- 确定影响营养状况的因素以及在ITx.之后停止管道养 (TFs) 的能力.
主要方法:
- 对133名在ITx后5年或更长时间生存的儿童 (1993-2014) 的回顾性分析.
- 在15年内评估生长参数,营养治疗和微量营养素状况.
- 分析因素包括口腔,类固醇使用,胃切除,发育延迟,并发移植和排斥.
主要成果:
- 在ITx后的15年中,身高z-score显著改善 (p < 0.001).
- 观察到BMI z分数的下降趋势.
- 推迟TF断奶的因素包括部分胃切除术,永久性骨髓切除术和发育迟缓.
结论:
- 儿科ITx导致长期线性增长的改善.
- 发育迟缓,部分胃切除术和永久性口腔切除术与ITx后的推迟TF断奶有关.
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