[新生儿和儿科的肠胃营养:物理化学稳定性,风险和预防措施. 叙述审查] 叙述审查]
Daisy Miranda Capetanópulos1, Valeria De Toro2
1Hospital Dr. Luis Calvo Mackenna, Santiago, Chile.
Andes pediatrica : revista Chilena de pediatria
|January 6, 2025
概括
亲肠道营养 (PN) 需要谨慎管理,因为它的复杂性和潜在的不稳定性. 本综述为增强PN物理化学稳定性提供了建议,特别是对于儿科和新生儿患者.
科学领域:
- 临床药房 临床药房
- 营养科学 营养科学
- 儿科医学 儿科医学
背景情况:
- 腹腔营养 (PN) 是一种复杂的疗法,涉及50多种营养素,由于度,pH值和药物相互作用而带来风险.
- 环境因素,如光,温度和氧气显著影响PN稳定性.
- 儿科和新生儿患者需要专门的PN由于代谢不成熟和更高的度需求,增加风险.
研究的目的:
- 根据SANRA标准,审查当前的亲肠道营养概念.
- 为改善PN混合物的物理化学稳定性提供基于证据的建议.
- 解决儿科和新生儿群体中PN的独特挑战.
主要方法:
- 系统的文献审查遵循叙事评论文章评估尺度 (SANRA).
- 分析影响PN物理化学稳定性的因素,包括营养成分组成和环境条件.
- 综合建议,以减少PN配方中的不稳定风险.
主要成果:
- 环境条件和特定的营养投入 (氨基酸,脂质,阴离子,离子,/盐) 极大地影响PN的稳定性.
- 在PN混合物制备中的变异性突显了对标准化协议的需求.
- 儿科/新生儿PN建议是最严格的,适用于成年人群.
结论:
- 优化PN物理化学稳定性对于患者安全至关重要,特别是在脆弱人群中.
- 遵守严格的指导方针,特别是从儿科/新生儿护理的指导方针,可以在所有患者群体中减轻风险.
- 需要进一步的研究来解决方法的多样性和标准化PN准备.
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