创伤后应激障碍及其与艾滋病毒退伍军人抗逆转录病毒治疗的关联
Kartavya J Vyas1,2,3,4, Vincent C Marconi2,5,6, Brian K Agan4,7
1Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta.
AIDS (London, England)
|January 6, 2025
概括
创伤后应激障碍 (PTSD) 与艾滋病毒退伍军人的抗逆转录病毒治疗 (ART) 不坚持和修改增加有关. 多次部署可能会使ART不坚持情况恶化,这突显了在这个人群中需要进行PTSD查的需要.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 心理健康 心理健康
背景情况:
- 创伤后应激障碍 (PTSD) 可以影响健康结果.
- 患有艾滋病毒的退伍军人 (VWH) 可能会在治疗坚持方面遇到独特的挑战.
- 退伍军人事务部 (VA) 为许多VWH提供护理.
研究的目的:
- 评估PTSD与抗逆转录病毒治疗 (ART) 坚持,修改和VWH失败之间的关系.
- 为了确定部署数量或战斗暴露是否会改变这些关联.
- 分析这些关联如何随着时间的推移而变化.
主要方法:
- 一个前性队列研究3206VWH在ART部署到伊拉克和阿富汗.
- 从ART启动到2022年12月收集的后续数据,共计22,261人年.
- 用于估计关联的边际结构模型,考虑时间依赖因素.
主要成果:
- 创伤后应激障碍与ART不坚持的风险增加6%有关.
- 创伤后应激障碍与38%更高的ART修改率有关.
- 多次部署放大了与ART不坚持的关联;战斗暴露没有改变关联.
结论:
- 创伤后应激障碍显著增加了与艾滋病毒感染的退伍军人的ART不遵守和修改.
- 对PTSD的查对于指导VWH治疗决策至关重要.
- 经过多次作战部署的退伍军人需要特别注意PTSD和ART管理.
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