辐射诱导的正常组织毒性与风湿性关节炎的高遗传风险相关
Alan McWilliam1,2, Deborah Marshall3,4, Sarah L Kerns5
1Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom.
Journal of the National Cancer Institute
|January 6, 2025
概括
风湿性关节炎 (RA) 的高多基因风险评分不会增加放射治疗的毒性. 这一发现表明,目前癌症患者的治疗计划不需要根据RA遗传风险进行修改.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 放射疗法是一种放射治疗.
背景情况:
- 类风湿性关节炎 (RA) 和DNA修复途径共享重叠的基因.
- 形成了一个假设,高多基因风险评分对RA可能会增加放射治疗毒性,这是由于共享的DNA修复机制.
研究的目的:
- 调查类风湿性关节炎 (RA) 的高多基因风险得分与癌症患者发展放射治疗毒性的风险之间的关联.
主要方法:
- 分析包括来自REQUITE研究的1494名前列腺癌,483名肺癌和1820名乳腺癌患者,以及来自放射遗传学联盟的验证队列.
- 一个多基因风险评分是使用从生殖基因组数据的101个RA风险变异计算的.
- 使用多变量模型分析了多基因风险得分和急性/晚期标准化总平均毒性 (STAT) 得分之间的关联.
主要成果:
- 没有观察到整体放射性毒性 (STAT-急性或STAT-晚期) 显著增加,同时所有队列中RA多原风险得分增加.
- 在肺癌患者中注意到晚期食道炎的潜在风险增加,但在随后的分析中没有得到验证.
- 在前列腺癌或乳腺癌队列中,没有任何个人急性或晚期毒性终点与RA多基因风险得分具有统计学意义的关联.
结论:
- 患有高遗传倾向性风湿性关节炎 (RA) 的患者不会表现出高辐射疗法毒性.
- 目前的放射治疗治疗计划策略不需要根据患者的类风湿性关节炎遗传风险概况进行修改.
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