化物暴露和儿童智商分数:系统性审查和元分析
Kyla W Taylor1, Sorina E Eftim2, Christopher A Sibrizzi2
1Division of Translational Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina.
JAMA pediatrics
|January 6, 2025
概括
这次审查发现,化物暴露与儿童智商得分较低有关. 即使在低水平下,饮用水和尿液中的化物也与认知发育有相反的关系.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 流行病学 流行病学
背景情况:
- 以前的元分析表明,化物暴露与儿童智商 (IQ) 之间存在负相关性.
- 个人暴露于化物的主要来源是饮用水,食物和饮料.
研究的目的:
- 进行流行病学研究的系统审查和元分析.
- 为了研究儿童智商得分与产前或产后化物暴露之间的关系.
主要方法:
- 在2023年10月之前搜索了多个数据库 (BIOSIS,Embase,PsycInfo,PubMed,Scopus,科学网,CNKI,万芳)
- 包括报告儿童智商得分,化物暴露和效应大小的研究.
- 提取数据,使用OHAT偏差风险工具评估研究质量,并使用随机效应模型估计聚合标准化平均差异 (SMD).
主要成果:
- 包括来自不同国家的74项研究 (64个横截面,10个队列),其中52项被评为具有偏见高风险的研究.
- 发现化物暴露与智商 (聚合SMD, -0.45) 之间的反向关联.
- 观察到饮用水 (SMD, -0.15) 和尿液 (SMD, -0.15) 中的化物与逆剂量反应相关,在个人水平分析中,每每1mg/L增加尿的IQ下降1.63点.
结论:
- 确认了化物暴露 (测量在尿液和饮用水中) 与儿童智商之间的反向和剂量反应关联.
- 在饮用水化物度低于1.5毫克/升时,确定了剂量反应关系的不确定性.
- 这些发现可以为化物暴露的公共健康风险和益处评估提供信息.
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