长效注射抗精神病药物在患有双极性障碍的青少年中
Parinda Parikh1, Kanuja Sood2, Lajpat Rai Bansal3
1Assistant Clinical Professor, Weill Cornell Medical College, New York, New York, USA.
Journal of child and adolescent psychopharmacology
|January 6, 2025
概括
长效的注射性抗精神病药物有效地控制了青少年的双相躁狂症,导致显著的症状减少和功能恢复. 这种非标签的使用表明,有望改善这一群体的治疗坚持.
科学领域:
- 儿童和青少年精神病学 儿童和青少年精神病学
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 双极性障碍在青春期发作可能会导致神经退行和功能衰退.
- 在青少年中,由于无意识症,认知问题和副作用,口服抗精神病药物的不良坚持是常见的.
- 长效注射 (LAI) 抗精神病药物是FDA批准的成人,但不是青少年,呈现治疗差距.
研究的目的:
- 为了评估非标签的LAI抗精神病药物的有效性和耐受性,在患有双相躁狂的青少年中使用.
- 通过年轻狂热评分表 (YMRS) 在一年内评估症状改善.
- 为了确定LAI抗精神病药物治疗青少年的功能恢复率.
主要方法:
- 一项对116名青少年 (平均年龄16.17) 的研究,他们被诊断患有双极性躁狂或精神分裂情绪障碍,双极型.
- 参与者每月,每两个月或每三个月接受LAI抗精神病药物 (aripiprazole, paliperidone,risperidone).
- 在基线和12个月后评估YMRS得分;并跟踪副作用和功能结果.
主要成果:
- 显著的YMRS得分从基线33.8降低到3.0在1年.
- 86.2%的青少年取得了足够的改善,重返学校或工作.
- 常见的副作用包括食欲增加和体重增加;12%的人更换配方,没有放弃或自杀企图.
结论:
- LAI抗精神病药物在稳定患有双相躁狂或精神分裂情绪障碍的青少年中表现出显著的疗效和耐受性.
- 在青少年中非标签使用LAI抗精神病药物显示了高缓解率和功能恢复.
- 需要进一步的FDA临床试验来探索青少年使用的经批准的LAI抗精神病药物配方.
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