性别,种族和菲茨帕特里克皮肤类型的代表性在梅拉斯马临床试验中
Journal of drugs in dermatology : JDD
|January 6, 2025
概括
梅拉斯马的临床试验显示越来越多的包容性,具有多元的种族代表性,并专注于菲茨帕特里克皮肤类型III和IV. 这一趋势凸显了皮肤病学研究中改善的人口平衡的趋势.
科学领域:
- 皮肤病学 皮肤病学
- 临床研究 临床研究
- 医学人口统计学 医学人口统计学
背景情况:
- 黑色素瘤是一种常见的色素性疾病,在全球范围内影响女性和肤色较深的人.
- 在了解瘤临床试验中的人口代表性方面存在很大的差距.
- 参与者的多样性对于研究结果的概括性至关重要.
研究的目的:
- 评估瘤临床试验参与者的人口代表性.
- 分析在注册患者中的性别,种族和菲茨帕特里克皮肤类型 (FST) 分布.
- 评价当前瘤研究的包容性.
主要方法:
- 在2024年3月2日进行了对ClinicalTrials.gov的全面搜索.
- 确定了符合纳入标准的19项瘤临床试验,涉及614名患者.
- 分析了包括性别,种族,种族和FST在内的人口统计数据.
主要成果:
- 女性患者占主导地位,占参与者的96.58%.
- 观察到种族和民族多样性:西班牙裔/拉丁裔 (43.10%),亚裔 (23.71%),白人 (15.52%) 和黑人/非洲裔美国人 (14.66%).
- 菲茨帕特里克皮肤类型III和IV占参与者的75%以上.
结论:
- 梅拉斯马的临床试验表明,越来越多的人正致力于包容性研究实践.
- 人口统计学概况表明,代表性有所改善,特别是在肤色不同的人群中.
- 这种包容性为皮肤病学研究影响不同人群的疾病创造了先例.
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