在第一期精神分裂症中异常的皮层形态网络
Fengmei Fan1, Suhui Jin2, Yating Lv3
1Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing 100096, China.
Schizophrenia bulletin
|January 6, 2025
概括
在第一发精神分裂症 (FES) 中,个性化的大脑网络被破坏. 这些网络中变化的形态相似性与症状相关,并将患者与对照区分开来,为精神分裂症提供了洞察力.
科学领域:
- 神经成像是一种神经成像.
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
背景情况:
- 基于人群的研究表明,精神分裂症的形态共变网络发生了变化.
- 个性化大脑网络方法是最近的发展.
研究的目的:
- 在第一发精神分裂症 (FES) 中调查个性化形态大脑网络的干扰.
- 确定这些干扰是否与临床症状和认知功能相关.
- 评估这些网络变化的诊断潜力.
主要方法:
- 为203名FES患者和131名对照组构建了单个受试者的形态大脑网络.
- 使用的区域皮层厚度,碎形尺寸,化指数和层深度.
- 采用了人类连接体项目的360个皮层区域的多模式分区地图.
主要成果:
- FES患者在网络类型之间表现出较少的形态相似性,碎形维度和形深度网络增加.
- 改变的相似之处在线圈-眼镜和默认模式网络中很突出.
- 网络变化与临床症状和认知缺陷相关,在区分患者方面优于局部形态学.
- 图形分析显示完整的全球组织,但在FES患者中改变了节点中心性.
结论:
- 第一发精神分裂症与单个主体皮质形态网络的明显破坏有关.
- 这些发现为精神分裂症的神经生物学机制提供了新的见解.
- 个性化网络分析为了解精神分裂症病理生理学提供了一个有希望的途径.
相关概念视频
Biological Causes of Schizophrenia
19
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
19
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
253
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
253
Positive Symptoms of Schizophrenia: Hallucinations and Delusions
33
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
33


