在皮层动态的威尔逊-考恩模型中,激发-抑制的平衡和分支控制
Francisco Páscoa Dos Santos1,2, Paul F M J Verschure3
1Eodyne Systems SL, Barcelona, Spain.
PLoS computational biology
|January 6, 2025
概括
刺激-抑制 (E-I) 稳态维持大脑发射率和两叉边缘动态. 多种E-I平衡机制确保稳定的网络活动和马振荡,这对皮质功能至关重要.
科学领域:
- 计算神经科学是一种计算神经科学.
- 系统神经科学 系统神经科学
- 神经动力学 神经动力学
背景情况:
- 刺激-抑制 (E-I) 平衡对于皮质电路功能至关重要.
- 现有的模型往往只关注抑制性可塑性,忽视了各种E-I平衡机制.
- 了解各种E-I恒温模式如何影响网络动态至关重要.
研究的目的:
- 为了研究多样化的E-I恒常机制如何塑造皮层网络中的振荡和两叉边缘动态.
- 探索不同EI恒温模式对在不同输入级别下保持稳定的燃烧速度的影响.
- 阐明使用多种恒温机制的功能益处.
主要方法:
- 使用威尔逊-考恩模型进行计算模拟.
- 分析了不同E-I恒温模式对网络活动的影响.
- 研究了火速和振荡频率的调制.
主要成果:
- E-I平衡可以有效地控制两叉边缘的动态.
- 某些恒温模式通过调整距离与分叉来维持高输入下的平均火速.
- 多种恒温机制确保了稳定的活动和生理振荡频率.
结论:
- 研究结果将E-I平衡,马振荡和两叉边缘动态与发射速率平衡联系起来.
- 提供了在皮层区域的两叉距离异质性的机制解释.
- 突出了各种家庭静止机制调节网络动态和马节奏的功能益处.
相关概念视频
The Role of Ion Channels in Neuronal Computation
3.1K
A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
3.1K
Propagation of Action Potentials
5.2K
The propagation of an action potential refers to the process by which a nerve impulse, or "action potential," travels along a neuron.
Neurons (nerve cells) have a resting membrane potential, with a slightly negative charge inside compared to outside. This is maintained by ion channels, such as sodium (Na+) and potassium (K+) channels, which control the flow of ions. When a stimulus, like a touch or a signal from another neuron, triggers the neuron, sodium channels open, allowing sodium ions to...
Neurons (nerve cells) have a resting membrane potential, with a slightly negative charge inside compared to outside. This is maintained by ion channels, such as sodium (Na+) and potassium (K+) channels, which control the flow of ions. When a stimulus, like a touch or a signal from another neuron, triggers the neuron, sodium channels open, allowing sodium ions to...
5.2K
Neural Circuits
1.0K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
1.0K
Root Loci for Positive-Feedback Systems
90
The Hartley oscillator is a positive feedback system that sustains oscillations by feeding the output back to the input in phase, thereby reinforcing the signal. Positive feedback systems can be viewed as negative feedback systems with inverted feedback signals. In these systems, the root locus encompasses all points on the s-plane where the angle of the system transfer function equals 360 degrees.
The construction rules for the root locus in positive feedback systems are similar to those in...
The construction rules for the root locus in positive feedback systems are similar to those in...
90
BIBO stability of continuous and discrete -time systems
335
System stability is a fundamental concept in signal processing, often assessed using convolution. For a system to be considered bounded-input bounded-output (BIBO) stable, any bounded input signal must produce a bounded output signal. A bounded input signal is one where the modulus does not exceed a certain constant at any point in time.
To determine the BIBO stability, the convolution integral is utilized when a bounded continuous-time input is applied to a Linear Time-Invariant (LTI) system....
To determine the BIBO stability, the convolution integral is utilized when a bounded continuous-time input is applied to a Linear Time-Invariant (LTI) system....
335
Action Potential
7.8K
Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they...
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they...
7.8K


